THE ASSOCIATION BETWEEN FATTY LIVER (NAFLD) DISEASE AND PCOS
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Přihlášení Registrace
Odkaz je uložen do schránky
Postavení
Sponzoři
Assy Nimer
KLINICKÉ HODNOCENÍ: NCT01735799
BioSeek: nct01735799
Klíčová slova
Abstraktní
Since both pathologies (PCOS and NAFLD) involve disturbed carbohydrate economy, which revolve around insulin resistance, it is tempting to examine the specific "liver profile" of women with PCOD. Furthermore, it would be of great importance if lean women who suffer from PCOD would be revealed to shere cardiovascular risks with their more overweight peers.
Patients - women who will be diagnosed with PCOD following their initial referal to our fertility clinic. Controls - normal ovulatory women who approached our fertility clinic due to either unexplained or male factor infertility.
Workup - history for menstrual pattern; Clinical evaluation for features of hyperandrogenism; ultrasonographic documentation of ovarian morphology; follicular phase hormonal profile for validation of the diagnosis and for ruling out other pathologies which may cause anovulation.
Liver profiling - The following blood tests will be used for the biochemical profiling: fasting glucose and insulin, CRP, HDL-cholesterol, triglycerides, AST, ALT, GGT, LDH, alkaline phosphatase, total bilirubin, direct bilirubin, ferritin, HBA1C and micro albumin ratio.
FibroScan® will be used to measure liver stiffness.
Termíny
| Poslední ověření: | 10/31/2012 |
| První předloženo: | 11/24/2012 |
| Odhadovaná registrace vložena: | 11/26/2012 |
| První zveřejnění: | 11/27/2012 |
| Poslední aktualizace byla odeslána: | 11/26/2012 |
| Poslední aktualizace zveřejněna: | 11/27/2012 |
| Aktuální datum zahájení studie: | 10/31/2012 |
Stav nebo nemoc
Polycystic Ovarian Syndrome,
Nonalcoholic Fatty Liver Disease
Fáze
-
Kritéria způsobilosti
| Věky způsobilé ke studiu | 18 Years Na 18 Years |
| Pohlaví způsobilá ke studiu | Female |
| Metoda vzorkování | Non-Probability Sample |
| Přijímá zdravé dobrovolníky | Ano |
| Kritéria | Workup - history for menstrual pattern; Clinical evaluation for features of hyperandrogenism; ultrasonographic documentation of ovarian morphology; follicular phase hormonal profile for validation of the diagnosis and for ruling out other pathologies which may cause anovulation. Liver profiling - The following blood tests will be used for the biochemical profiling: fasting glucose and insulin, CRP, HDL-cholesterol, triglycerides, AST, ALT, GGT, LDH, alkaline phosphatase, total bilirubin, direct bilirubin, ferritin, HBA1C and micro albumin ratio. FibroScan® will be used to measure liver stiffness, as previously described |
