Zhongguo Zhongyao Zazhi 2005-Apr
[Experimental study on treatment of minimal change nephropathy with Lespedeza michx].
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Přihlášení Registrace
Odkaz je uložen do schránky
Klíčová slova
Abstraktní
OBJECTIVE
To study the therapeutic effect of Lespedeza Michx in experimental rat model of minimal change nephropathy (MCN).
METHODS
The rat MCN model was reproduced by tail-intravenous injection of Adriamycin. The treatment effect of Lespedeza Michx was determined by the detection of urine protein collection for 24 hours, malondialdehyde (MDA), superoxide dismutase (SOD), ATCO, IL-8, TNF-alpha in serum, and renal histopathological changes were observed by microscope.
RESULTS
Lespedeza Michx could decrease the contents of urine proteinuria, MDA, IL-8, and TNF-alpha in serum, increase SOD level and improved the pathological change of glomeruli.
CONCLUSIONS
Lespedeza Michx was effective on MCN.
