Patients undergoing incision and drainage of abscess will undergo an initial medical assessment including the history, physical examination, and vital signs. The patients will then receive Nitrous Oxide gas via a gas mixer device while undergoing standard incision and drainage of cutaneous abscess using lidocaine local anesthesia administered subcutaneously. The device will mix and deliver nitrous oxide and oxygen in a 1:1 ratio, at a fixed concentration of 50%/50%. The on demand valve requires patient inspiration to trigger dosing.

Patients undergoing incision and drainage of abscess will undergo an initial medical assessment including the history, physical examination, and vital signs. The patients will then receive 100% oxygen gas via the Nitrous Oxide gas mixer device while undergoing standard incision and drainage of cutaneous abscess using lidocaine local anesthesia administered subcutaneously. The device will deliver only oxygen at a fixed concentration of 100%. The on demand valve requires patient inspiration to trigger dosing.

Abscess

Patients undergoing incision and drainage of abscess will undergo an initial medical assessment including the history, physical examination, and vital signs. The patients will then receive Nitrous Oxide gas via a gas mixer device while undergoing standard incision and drainage of cutaneous abscess . The device will mix and deliver nitrous oxide and oxygen in a 1:1 ratio, at a fixed concentration of 50%/50%. The on demand valve requires patient inspiration to trigger dosing.

Nitrous Oxide

Patients undergoing incision and drainage of abscess will undergo an initial medical assessment including the history, physical examination, and vital signs. The patients will then receive 100% oxygen gas via the Nitrous Oxide gas mixer device while undergoing standard incision and drainage of cutaneous abscess . The device will deliver only oxygen at a fixed concentration of 100%. The on demand valve requires patient inspiration to trigger dosing.

Oxygen

Einstein Medical Center Philadelphia

Adjunctive Nitrous Oxide During ED Incision and Drainage of Abscess

Adjunctive Nitrous Oxide to Lidocaine Anesthesia During ED Incision and Drainage of Abscess in Adults: A Randomized Controlled Trial

VAS measured pre-anesthesia, pre-procedure, immediately post procedure, and 10 minutes following procedure.

Total number of minutes Nitrous oxide was inhaled by patients

Physician satisfaction with use of Nitrous oxide/Oxygen in pain control

Patient satisfaction with use of Nitrous oxide/Oxygen in pain control

Oxygen saturation measured every 20 milliseconds captured by a monitoring device during study period

End tidal Co2 measured every 20 milliseconds captured by a monitoring device during study period

Joseph Herres

Research Director

Albert Einstein Healthcare Network

Emergency Medicine Foundation

No intervention patient will receive current standard of care treatment and will answer surveys to collect data.

Patient will receive lavender essential oil topically and by inhalation during their hospital stay while at the same time receiving regular standard of care.

Pain, Postoperative

Lavender essential oil will be applied topically and by inhalation to the lavender group.

Lavender Essential Oil

Duke University Medical Center

Effects of Lavender Oil on Postoperative Pain, Sleep Quality and Mood

assess pain through pain scores documented in medical record compared to control group

assess pain through documentation of total narcotic use compared to the control group

assess pain through daily pain satisfaction survey score compared to control group

assess sleep quality by Richards Campbell sleep questionnaire survey

assess anxiety by hospital anxiety depression scale survey

Scott Hollenbeck, MD

Surgeon

dōTERRA International

Randomized study with control group and test group. Using a 1:1 treatment allocation ratio, the total of 60 patients (30 per arm) will be randomly assigned to control or treatment arm. The Statistical Investigator will generate the randomization scheme and monitor the randomization process over the course of the trial. The study will use randomization with random permuted blocks. The test group will receive 50% lavender oil diluted in fractionated coconut oil and the control group will have the current standard of care with no essential oil intervention. Fractionated coconut oil is being used because it is colorless, odorless, does not stain clothing, and has a long shelf life. It also serves as a carrier oil for the essential oil to absorb into the skin instead of evaporating off the skin due to essential oils volatile nature.

Clonazepam (Klonopin®) treatment arm - 1 mg clonazepam (Klonopin® tablet) TID, dissolved in mouth for 3 minutes then expectorated

Mucolox® only - 5mL Mucolox® TID, swished around mouth for 3 minutes then expectorated

Mucolox® and clonazepam - 1mg Clonazepam/5mL Mucolox® TID, swished around mouth for 3 minutes then expectorated.

Burning Mouth Syndrome

1mg clonazepam in 5mL Mucolox® will be used TID. Mixture will be swished around mouth for 3 minutes then spat out.

Clonazepam mixed with Mucolox®

5mL Mucolox® TID. Mixture swished around mouth for 3 minutes then spat out.

Mucolox® alone

1mg Clonazepam tablet will be used TID. Tablet dissolved in mouth, swished around and then expectorated.

anxiolytic/zubní kaz

Adjunctive Nitrous Oxide During ED Incision and Drainage of Abscess

Effects of Lavender Oil on Postoperative Pain, Sleep Quality and Mood

Effectiveness of Mucolox® and Clonazepam in Treatment of Burning Mouth Syndrome

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