Two capsules containing starch and glucose, once per day, 60 days duration

One capsule 250 mg active compound (OPP) and one capsule containing starch and glucose, once per day, 60 days duration

One capsule containing 1000 mg active compound (OPP) and one capsule starch and glucose, once per day, 60 days duration

Two capsules, 1000 mg active compound (OPP) each, once per day, 60 days duration

Cardiovascular Diseases

Hyperlipidemias

Hypercholesterolemia

The placebo that will be used contains starch and glucose.

Placebos

One capsule contains 250 mg OPP or 1 g OPP

Oil Palm Phenolics

National University of Malaysia

Supplementation of Oil Palm Phenolics to Healthy Participants

Supplementation of Oil Palm Phenolics to Improve Lipid Profile in Healthy Participants (Phase I Clinical Trial Study)

This will be assessed from the plasma analysis on the fasting blood samples of each participant

This will be assessed via history, physical examination, kidney function test, liver function test and hematology profile from the plasma analysis on the fasting blood samples of each participant.

This will be assessed from the plasma analysis on the fasting blood samples of each participant.

Inflammatory markers such as Interleukin-6, Interleukin-1beta, Tumour Necrosis Factor-alpha, Interleukin-10 and interferon-Gamma will be assessed from the plasma analysis on the fasting blood samples of each participant.

Antioxidant levels such as Malonaldehyde and Superoxide dismutase will be assessed from the plasma analysis on the fasting blood samples of each participant.

This will be assessed by measuring the weight of each participant.

Isa Naina Mohamed

Associate Professor

Malaysia Palm Oil Board

500 mg gallic acid equivalent (GAE), twice daily, 12 months

Prediabetes

Placebo

Seberang Jaya Hospital

Modulating Effects of Oil Palm Phenolics in Subjects With Pre-diabetes

Serum Glycosylated Haemogoblin (<5.7% indicates healthy, 5.7% - 6.4% indicates prediabetes, >6.5% indicates diabetes)
Plasma glucose level of oral glucose tolerance test (<7.8 mmol/L indicates healthy, 7.8 mmol/L - 11 mmol/L indicates prediabetes, >11 mmol/L indicates diabetes)
Fasting plasma glucose level (<5.6 mmol/L indicates healthy, 5.6 mmol/L - 6.9 mmol/L indicates prediabetes, >6.9 mmol/L indicates diabetes)

Model-derived Oral Glucose Insulin Sensitivity (OGIS) Index will be calculated using weight (kg), height (cm), glucose (mmol/L) and insulin (pmol/L).

Total cholesterol, Low-density lipoprotein, High-density lipoprotein, Triglycerides

Very good, good, no change, unsatisfactory and very unsatisfactory

Homeostatic Model Assessment (HOMA2-B) to determine beta cell function

Yuen Kah Hay

Professor, Dr.

Universiti Sains Malaysia

Clinical Research Centre, Malaysia

500 mg gallic acid equivalent (GAE), twice daily, 3 months

Uncontrolled Insulin-treated Type 2 Diabetes Mellitus

Modulating Effects of Oil Palm Phenolics in Uncontrolled Insulin-treated Type 2 Diabetes Mellitus

Very good, Good, No change, Unsatisfactory, Very unsatisfactory

elaeis/protizánětlivé

Supplementation of Oil Palm Phenolics to Healthy Participants

Modulating Effects of Oil Palm Phenolics in Subjects With Pre-diabetes

Modulating Effects of Oil Palm Phenolics in Uncontrolled Insulin-treated Type 2 Diabetes Mellitus

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