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huntington disease/triglyceride

Odkaz je uložen do schránky
ČlánkyKlinické testyPatenty
12 Výsledek

A Metabolic Study of Huntington's Disease.

Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
BACKGROUND Huntington's disease patients have a number of peripheral manifestations suggestive of metabolic and endocrine abnormalities. We, therefore, investigated a number of metabolic factors in a 24-hour study of Huntington's disease gene carriers (premanifest and moderate stage II/III) and

Blood Oxidative Stress Marker Aberrations in Patients with Huntington's Disease: A Meta-Analysis Study

Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
Huntington's disease (HD) is a hereditary autosomal dominant neurodegenerative disease. Although studies have shown that blood oxidative stress markers are dysregulated in HD patients, clinical data on the blood oxidative stress markers of HD patients is inconsistent. To better understand the

Altered hypothalamic protein expression in a rat model of Huntington's disease.

Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
Huntington's disease (HD) is a neurodegenerative disorder, which is characterized by progressive motor impairment and cognitive alterations. Changes in energy metabolism, neuroendocrine function, body weight, euglycemia, appetite function, and circadian rhythm can also occur. It is likely that the

Subventricular zone lipidomic architecture loss in Huntington's disease.

Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
The human subventricular zone (SVZ) has a defined cytological and neurochemical architecture, with four constituent laminae that act in concert to support its neurogenic activity. Lipidomic specialisation has previously been demonstrated in the neurologically normal human SVZ, with enrichment of
It was the aim of this study to establish triglyceride matrices as potential carriers for long-term release of brain-derived neurotrophic factor (BDNF), a potential therapeutic for Huntington's disease. First, four different manufacturing strategies were investigated with lysozyme as a model

Development and Clinical Applications of Antisense Oligonucleotide Gapmers

Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
DNA-like molecules called antisense oligonucleotides have opened new treatment possibilities for genetic diseases by offering a method of regulating gene expression. Antisense oligonucleotides are often used to suppress the expression of mutated genes which may interfere with essential downstream

HdhQ111 Mice Exhibit Tissue Specific Metabolite Profiles that Include Striatal Lipid Accumulation.

Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
The HTT CAG expansion mutation causes Huntington's Disease and is associated with a wide range of cellular consequences, including altered metabolism. The mutant allele is expressed widely, in all tissues, but the striatum and cortex are especially vulnerable to its effects. To more fully understand

Essential fatty acid-rich diets protect against striatal oxidative damage induced by quinolinic acid in rats.

Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
Essential fatty acids have an important effect on oxidative stress-related diseases. The Huntington's disease (HD) is a hereditary neurologic disorder in which oxidative stress caused by free radicals is an important damage mechanism. The HD experimental model induced by quinolinic acid (QUIN) has
Peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1 alpha) is a protein that regulates metabolism and inflammation by activating nuclear receptors, especially the family of peroxisome proliferator-activated receptors (PPARs). PGC-1 alpha and PPARs also regulate mitochondrial
The omega-3 fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are orthomolecular, conditionally essential nutrients that enhance quality of life and lower the risk of premature death. They function exclusively via cell membranes, in which they are anchored by phospholipid
The assessment of comorbid physical illness and metabolic or cardiovascular risk factors as potential risk factors for onset of major depressive disorder (MDD) is crucial. We aimed to investigate potential risk factors for the development of MDD among individuals with chronic medical

Triheptanoin for the treatment of brain energy deficit: A 14-year experience.

Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
Triheptanoin is an odd-chain triglyceride with anaplerotic properties-that is, replenishing the pool of metabolic intermediates in the Krebs cycle. Unlike even-chain fatty acids metabolized to acetyl-CoA only, triheptanoin can indeed provide both acetyl-CoA and propionyl-CoA, two key carbon sources
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