The present invention provides for filariid nematode cysteine protease proteins; to filariid nematode cysteine protease nucleic acid molecules, in particular, Dirofilaria immitis L3 larval cysteine protease nucleic acid molecules and Onchocerca volvulus L3 larval cysteine protease nucleic acid molecules; to antibodies raised against such proteins, and to compounds that inhibit filariid nematode cysteine protease activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies and/or inhibitors. The present invention also includes therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitors, and the use of such compositions to protect an animal from disease caused by parasitic helminths.

Heska Corporation

Colorado State University Research Foundation

Filariid nematode cysteine protease proteins, and uses thereof

intestinal volvulus/protease

Filariid nematode cysteine protease proteins, and uses thereof

Filariid nematode cysteine protease nucleic acid molecules and uses thereof

Dirofilaria and onchocerca larval L3 cysteine protease proteins and uses thereof

Filariid nematode cysteine protease proteins, nucleic acid molecules and uses thereof

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