A method of effecting contraception in human females comprises administering an ovulation-inhibiting amount of melatonin. Optionally, the melatonin is administered in combination with a progestogen and/or an estrogen. The administration of melatonin also provides a method of preventing breast cancer in women.

Applied Medical Research

Compositions and methods of effecting contraception utilizing melatonin

A combination hormone and melatonin therapy is provided to reduce the risk of developing, or to reduce the severity of, breast cancer by administering at least one estrogen hormone and optionally at least one progesterone-receptor-binding compound or composition and melatonin together, preferably at normal bed time.

Duquesne University of the Holy Spirit

Combination hormone replacement therapy (HRT) and melatonin to prevent and treat mammary cancer

Witt-Enderby; Paula A

Davis; Vicki L

A particularly constructed tamoxifen-melatonin hybrid ligand gives new and unexpectedly improved results in the prevention and treatment of cancer, particularly breast cancer. The hybrid ligand comprises either tamoxifen or 4-hydroxytamoxifen and also melatonin, with the tamoxifen or 4-hydroxytamoxifen and melatonin's being linked by an unsubstituted C.sub.2-C.sub.6 alkyl linker between the tamoxifen amine and the carbonyl of melatonin.

melatonin/karcinom prsu

Compositions and methods of effecting contraception utilizing melatonin

Combination hormone replacement therapy (HRT) and melatonin to prevent and treat mammary cancer

Combination hormone replacement therapy (HRT) and melatonin to prevent and treat mammary cancer

Anti-cancer tamoxifen-melatonin hybrid ligand

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