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In six carcinogenicity bioassays, male and female F344 rats were fed diets containing aniline hydrochloride (CAS: 142-04-1; hydrochloride benzenamide), p-chloroaniline (CAS: 106-47-8), azobenzene (CAS: 103-33-3), o-toluidine hydrochloride (CAS: 636-21-5), dapsone (CAS: 80-08-0;
A bioassay of o-toluidine hydrochloride for possible carcinogenicity was conducted by administering the test chemical in feed to F344 rats and B6C3F1 mice. Groups of 50 rats of each sex and 50 mice of each sex were administered o-toluidine hydrochloride at one of several doses, either 3,000 or 6,000
Ortho-toluidine carcinogenicity has been tested in chronic experiments using mice, rats and dogs. Tumors were induced in 19% of mice (lung and kidney adenomas, leukemia), rats--40% (subcutaneous fat tumors, mammary fibroadenomas, leukemia, renal tumors and hepatic sarcoma). Bladder tumors developed
Since 1988, the National Institute for Occupational Safety and Health (NIOSH) has notified workers who were subjects in occupational epidemiology studies of the study findings ("worker notification"). This paper describes seven notifications and the worker's reactions to them. The chemicals of