Obesity

Metabolic Syndrome

Placebo fecal microbial transplantation (FMT)

Placebo FMT

combined fiber supplement of resistant starch type 4, acacia gum, and soluble corn fiber

Prebiotic Fiber

Cellulose

Royal Alexandra Hospital

Fecal Microbial Transplantation and Fiber Supplementation in Participants With Obesity and Metabolic Syndrome.

The primary endpoint is the change in insulin sensitivity between the time of screening and 6 weeks following treatment.

weight and height will be combined to report changes in BMI in kg/m^2 between baseline and 6 and 12 weeks

Changes in waist to hip circumferences between baseline and 6 and 12 weeks

Changes HbA1C between baseline and 6 and 12 weeks

Changes fasting glucose between baseline and 6 and 12 weeks

Changes in oral glucose tolerance between baseline and 6 and 12 weeks

Changes in Fasting lipid profile between baseline and 6 and 12 weeks

Changes in blood pressure between baseline and 6 and 12 weeks

Changes in EuroQol five dimensions questionnaire scores to arrive at the participants quality of life between baseline and 6 and 12 weeks

The SLIM Hunger and satiety questionnaire scores used to arrive at the participants feelings of hunger and satiety. Changes in reported feelings of Hunger and Satiety between baseline and 6 and 12 weeks

Changes in serum levels of leptin, adiponectin, ghrelin, CRP, TNF-α, IL-6, LPS, and LPS-binding protein between baseline and 6 and 12 weeks

Changes in fecal microbiota composition between baseline and 6 and 12 weeks

Changes in stool short chain fatty acid composition between baseline and 6 and 12 weeks

senegalia/triglyceride

Fecal Microbial Transplantation and Fiber Supplementation in Participants With Obesity and Metabolic Syndrome.

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