Hormone Estradiol Replacement Therapy Additional Herbals
Nøgleord
Abstrakt
Beskrivelse
Recent studies have proved :
-Garlic oil as garlic may reduce platelet aggregation, patients taking anticoagulant medication are cautioned about consuming garlic.
A 2013 meta-analysis concluded that garlic preparations may effectively lower total cholesterol by 11-23 mg/dL and LDL cholesterol by 3-15 mg/dL in adults with high cholesterol if taken for longer than two months. The same analysis found that garlic had a marginally positive effect on HDL cholesterol, no significant effect on blood triglyceride levels, and that garlic preparations were generally well tolerated with very few side effects.
- Nattokinase Nattō is made from fermented soybeans and has been eaten in Japan for about a thousand years. Nattō is produced by fermentation by adding the bacterium Bacillus natto to boiled soybeans. Nattokinase is produced by the bacterium acting on the soybeans . While other soy foods contain enzymes, it is only the nattō preparation that contains the specific nattokinase enzyme.
- Estradiol valerate is one of the most widely used esters of estradiol.
- Progesterone: Hormone replacement therapy. Progesterone is combined with 17-beta estradiol in the estrogen patch.
Datoer
| Sidst bekræftet: | 08/31/2018 |
| Først indsendt: | 11/13/2015 |
| Anslået tilmelding indsendt: | 11/25/2015 |
| Først indsendt: | 11/30/2015 |
| Sidste opdatering indsendt: | 09/11/2018 |
| Sidste opdatering indsendt: | 09/13/2018 |
| Faktisk startdato for undersøgelsen: | 12/31/2008 |
| Anslået primær afslutningsdato: | 05/31/2015 |
| Anslået afslutningsdato for undersøgelsen: | 05/31/2015 |
Tilstand eller sygdom
Intervention / behandling
Drug: ESTROGEN HERBALS 21
Drug: ESTROGEN HERBALS 28
Fase
Armgrupper
| Arm | Intervention / behandling |
|---|---|
| Experimental: ESTROGEN HERBALS 21 Used for women who wish to monthly menstruation
Applies to the following strengths:
17β-estradiol 1.5mg/24 hours x 21 days, stop drinking for 7 days. Progesterone 5mg/24 hours x 10 days, stop drinking for 7 days. Garlic oil 30mg/24 hours x 28 days. Enzyme nattokinase 300 FU x 24 hours x 28 days. | Drug: ESTROGEN HERBALS 21 Applies to the following strengths:
17β-estradiol 1.5mg/24 hours x 21 days, stop drinking for 7 days. Progesterone 5 mg/24 hours x 10 days, stop drinking for 7 days. Garlic oil 30mg/24 hours x 28 days. Enzyme nattokinase 300 FU x 24 hours x 28 days. |
| Experimental: ESTROGEN HERBALS 28 Used for women who do not wish to monthly menstruation
Applies to the following strengths:
17β-estradiol 1.5mg/24 hours x 28 days. Garlic oil 30mg/24 hours x 28 days. Enzyme nattokinase 300 FU x 24 hours x 28 days. | Drug: ESTROGEN HERBALS 28 Applies to the following strengths:
17β-estradiol 1.5mg/24 hours x 28 days. Garlic oil 30mg/24 hours x 28 days. Enzyme nattokinase 300 FU x 24 hours x 28 days. |
Kriterier for støtteberettigelse
| Alder berettiget til undersøgelse | 35 Years Til 35 Years |
| Køn, der er berettiget til undersøgelse | Female |
| Accepterer sunde frivillige | Ja |
| Kriterier | Inclusion Criteria: - Hormone replacement therapy (HRT) for oestrogen deficiency symptoms in perimenopausal and postmenopausal women. - Prevention of osteoporosis in postmenopausal women at high risk of future fractures who are intolerant of, or contraindicated for, other medicinal products approved for the prevention of osteoporosis. Exclusion Criteria: - Known, past or suspected breast cancer; - Known or suspected oestrogen-dependent malignant tumours (eg endometrial cancer); - Undiagnosed genital bleeding; - Untreated endometrial hyperplasia; - Previous or current venous thromboembolism (deep venous thrombosis,pulmonary embolism) - Known thrombophilic disorders (eg protein C, protein S, or antithrombin deficiency, see section. - Active or recent arterial thromboembolic disease (eg angina, myocardial infarction); - Acute liver disease, or a history of liver disease as long as liver function tests have failed to return to normal; - Known hypersensitivity to the active substances or to any of the excipients; |
Resultat
Primære resultatforanstaltninger
1. Time to Estradiol > 35 pg / ml [1 years]
Sekundære resultatforanstaltninger
1. Time to Estradiol > 35 pg / ml [2 years]
