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12 resultater
Total aralosides of aralia elata (Miq) seem (TASAES) ameliorate nonalcoholic steatohepatitis by modulating IRE1α-mediated JNK and NF-κB pathways in ApoE-/- mice.
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BACKGROUND
Total saponins of Aralia elata (Miq) Seem (TASAES) from the Chinese traditional herb Long ya Aralia chinensis L. is popularly used as a folk medicine to treat rheumatism, neurasthenia, diabetes, hepatitis and antivirus in Asian countries. However, there was poor study of TASAES on
SIRT1/AMPK and Akt/eNOS signaling pathways are involved in endothelial protection of total aralosides of Aralia elata (Miq) Seem against high-fat diet-induced atherosclerosis in ApoE-/- mice.
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Total aralosides of Aralia elata (Miq) Seem (TASAESs) possess multiple pharmacological activity, such as anti-inflammation, antioxidation, and antiapoptosis. However, there is no literature reporting the antiatherosclerotic effect and mechanism of TASAES so far. The aim of this study was to
Protective effect of total aralosides of Aralia elata (Miq) Seem (TASAES) against diabetic cardiomyopathy in rats during the early stage, and possible mechanisms.
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Total aralosides of Aralia elata (Miq) Seem (TASAES) from Chinese traditional herb Longya Aralia chinensis L was found to improve cardiac function. The present study was to determine the protective effects of TASAES on diabetic cardiomyopathy, and the possible mechanisms. Therefore, a single dose of
Araloside A, an antiulcer constituent from the root bark of Aralia elata.
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Araloside A, a potent inhibitor of gastric lesion and ulcer formation in rats, was isolated from the root bark of Aralia elata through a bioassay-guided separation procedure. The compound exhibited significant reduction of HCl.ethanol-induced gastric lesions and aspirin-induced gastric ulcers at
Protective effects of Araloside C against myocardial ischaemia/reperfusion injury: potential involvement of heat shock protein 90.
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The present study was designed to investigate whether Araloside C, one of the major triterpenoid compounds isolated from Aralia elata known to be cardioprotective, can improve heart function following ischaemia/reperfusion (I/R) injury and elucidate its underlying mechanisms. We observed that
Araloside C Prevents Hypoxia/Reoxygenation-Induced Endoplasmic Reticulum Stress via Increasing Heat Shock Protein 90 in H9c2 Cardiomyocytes.
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Araloside C (AsC) is a cardioprotective triterpenoid compound that is mainly isolated from Aralia elata. This study aims to determine the effects of AsC on hypoxia-reoxygenation (H/R)-induced apoptosis in H9c2 cardiomyocytes and its underlying mechanisms. Results demonstrated that pretreatment with
[Determination of total aralosides in Aralia mandshurica grown in Jilin and Liaoning Provinces].
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[Determination of the sum of aralosides A, B, C in the roots of Aralia mandshurica].
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[Studies on the chemical constituents from Aralia elata].
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Eight compounds have been isolated from the root bark of Aralia elata. Their structures have been identified by means of physico-chemical and spectral analysis. They are (6'-O-palmitoyl)-beta-sitosterol-3-O-beta-D-glucoside (A5), silphiosideA (A9), chikusetusaponin Ib (A11), araloside A (A12),
[Studies on the saponins from the root bark of Aralia chinensis L].
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Six saponins were isolated from the root bark of Aralia chinensis L.. The three saponins I, II and III were identified as araloside A (I), narcissiflorine (II) and oleanolic acid 3-O-beta-D-glucopyranosyl-(1-2)-beta-D-xylopyranosyl-(1-2)-alpha-L- arabinopyranoside (III). Saponin III was found to be
Triterpenoid saponins from the roots of Aralia spinifolia.
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Two new triterpenoid saponins named aralosides H[1] and J [2], along with four known triterpenoid saponins 3-6 were isolated from the roots of Aralia spinifolia. Their structures were determined as 3-O-beta-D-xylopyranosyl-(1-->2)-[beta-D-glucuronopyranosyl (1-->3)]-beta-D-glucopyranosyl-oleanolic
[Oleanolic acid saponins from the root bark of Aralia taibaiensis].
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Five oleanolic acid saponins were isolated from the root bark of Aralia taibaiensis Z.Z. Wang et H.C. Zheng. By spectroscopic and chemical methods, they were identified as araloside A (1), 3-O-[alpha-L-arabinofuranosyl(1-->4)-6'-O-n-butyl-beta-D- glucuronopyranosyl]-oleanolic
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