Sesquiterpene lactones, secondary metabolites of plants, present in a large number of species mostly from the Asteracea family, were used in the traditional medicine of many countries for the treatment of various pathological conditions. They exert a broad range of activities, including
Arnica montana L. (plant family: Compositae) is one of the oldest and most important drug plants. Besides its healing effects it also reveals sensitizing properties. From the literature more than 35 references with more than 100 cases of contact dermatitis could be cited, completed by four own
Some sesquiterpene lactones and related compounds were tested for anti-inflammatory activity in rodents. In the edema-induced carrageenan inflammation screen, the alpha-methylene-gamma-lactone moiety of the sesquiterpene lactones was required for inhibitory activity. The 6-hydroxy group of helenalin
Sesquiterpene lactones are a large group of secondary plant metabolites mostly known from the Asteraceae family. They exert a broad variety of different biological activities. This review attempts to critically summarise the knowledge on the anti-inflammatory and cytotoxic activity of SLs, with a
Three patients with occupational contact dermatitis due to Arnica longifolia Eaton and Arnica montana L. are reported. During cultivation, harvesting of the flower heads, chemical investigation of the sesquiterpene lactone constituents and preparation of therapeutic tinctures, they had frequent
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