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radiculopathy/protease
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The role of spinal thrombin through protease-activated receptor 1 in hyperalgesia after neural injury.
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OBJECTIVE Painful neuropathic injuries induce blood-spinal cord barrier (BSCB) breakdown, allowing pro-inflammatory serum molecules to cross the BSCB, which contributes to nociception. The goal of these studies was to determine whether the blood-borne serine protease thrombin also crosses a
Epidural spinal lipomatosis with acute onset of paraplegia in an HIV-positive patient treated with corticosteroids and protease inhibitor: case report.
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METHODS
Case report.
OBJECTIVE
To report a case of HIV-related lipodystrophy with a rapid onset of symptoms from epidural lipomatosis in the wake of protease inhibitor and steroid treatment.
BACKGROUND
Symptomatic spinal epidural lipomatosis is considered to be a rare condition usually presenting
Salmon and human thrombin differentially regulate radicular pain, glial-induced inflammation and spinal neuronal excitability through protease-activated receptor-1.
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Chronic neck pain is a major problem with common causes including disc herniation and spondylosis that compress the spinal nerve roots. Cervical nerve root compression in the rat produces sustained behavioral hypersensitivity, due in part to the early upregulation of pro-inflammatory cytokines, the
Tissue type plasminogen activator induced in rat dorsal horn astrocytes contributes to mechanical hypersensitivity following dorsal root injury.
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Dorsal root injury is known to induce alteration of the extracellular environment in the spinal cord and synaptic reorganization with degradation of injured primary afferent and sprouting of spared terminal. These changes affect behavioral sensitivity and sometimes lead to neuropathic pain. We have
The role of mast cells in disc herniation inflammation.
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METHODS
A study of herniated lumbar disc tissue samples and control disc material to determine the presence of mast cells in disc herniations.
OBJECTIVE
To analyze whether mast cells have any involvement in disc herniation pathophysiology and lumbar pain, because mast cells may have an important
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