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6 resultater
Isolation and antiproliferation of tumor cells by a novel peptide (TC22) from the beetle Tribolium castaneum.
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Anticancer peptides (ACPs) are biologically anticancer active molecules that are produced by mammals, plants, insects and microorganisms. Here, a new peptide (TC22) with the amino acid sequence MTVVLLLIVLPLLGGVHSSGIL was identified and characterized from the beetle Tribolium castaneum. We found it
Flour infested with Tribolium castaneum, biscuits made of this flour, and 1,4-benzoquinone induce neoplastic lesions in Swiss albino mice.
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The carcinogenic effect of flour infested with beetles (Tribolium castaneum), biscuits made of this flour, and 1,4-benzoquinone (a quinoid secretion of this beetle) was investigated using Swiss albino mice. Force feeding flour infested with T. castaneum induced liver and spleen tumors
Carcinogenicity of flour infested with Tribolium castaneum using the Egyptian toad Bufo regularis as a biological test animal.
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Feeding the Egyptian toad Bufo regularis for 14 weeks with flour infested for 1 year with Tribolium castaneum, at a dose level of 200 mg/50 g body weight, induced neoplasms in 22 out of 100 toads. These neoplasms comprise 22 primary hepatocellular carcinomas and 6 tumours in the kidney due to
Carcinogenic effect of biscuits made of flour infested with Tribolium castaneum in Bufo regularis.
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Biscuits made of flour infested with Tribolium castaneum induced the formation of hepatocellular carcinomas (22%) when force-fed to toads (Bufo regularis) at a dose level of 200 mg/50 g 3 times a week. Maximal time of exposure and observation was 16 weeks. Some metastatic deposits from the primary
Structure of the Tribolium castaneum telomerase catalytic subunit TERT.
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A common hallmark of human cancers is the overexpression of telomerase, a ribonucleoprotein complex that is responsible for maintaining the length and integrity of chromosome ends. Telomere length deregulation and telomerase activation is an early, and perhaps necessary, step in cancer cell
TC003132 is essential for the follicle stem cell lineage in telotrophic Tribolium oogenesis.
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BACKGROUND
Stem cells are undifferentiated cells with a potential for self-renewal, which are essential to support normal development and homeostasis. To gain insight into the molecular mechanisms underlying adult stem cell biology and organ evolution, we use the telotrophic ovary of the beetle
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