Potassium uptake in normal and crown-gall tissue culture cells of Vinca rosea L. (Cathalanthus roseus G. Don.) was studied. When grown on White's medium for 14-20 d, the tumor cells had a higher K(+) content that did the normal cells. At this logarithmic stage of growth, the rate of K(+) uptake was
The reported stereoscan images have proved that overtherapeutic amounts of vincristine induce in normal red cells the same effects as vinblastine, i.e. the onset of spherocytosis (in about 30% of the cells) and spherostomatocytosis (in the remainder) associated with distinct smaller vacuoles
A reliable HPLC method coupled with DAD detection was developed and validated for determination of majdine in Vinca herbacea. The chromatographic separation was carried out on a Symmetry C18 column (250 mm x 4.6 mm, 5 microm, Waters) with an isocratic solvent system of 25 mM potassium phosphate
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