Effect of Probiotic on Oral Health of Children
Schlüsselwörter
Abstrakt
Beschreibung
Probiotic bacteria are used in the prevention and treatment of gastrointestinal diseases and infections, including the treatment of oral diseases. Probiotic bacteria can be found in saliva, plaque and adhering directly to the mucous membrane. They compete with cariogenic bacteria and pathogens of periodontal disease. Increased interest in probiotics means that attempts are being made to find new solutions regarding the methods of their administration. The use of probiotic bacteria brings beneficial health effects. Lactobacillus salivarius is a strain isolated from human milk. It is inactive (heat treatment) and therefore does not produce metabolites that can promote the formation of carious lesions in the mouth by lowering the mouth potential of hydrogen.
Termine
| Zuletzt überprüft: | 05/31/2019 |
| Zuerst eingereicht: | 04/14/2019 |
| Geschätzte Einschreibung eingereicht: | 04/16/2019 |
| Zuerst veröffentlicht: | 04/17/2019 |
| Letztes eingereichtes Update: | 10/29/2019 |
| Letztes Update veröffentlicht: | 10/30/2019 |
| Tatsächliches Startdatum der Studie: | 07/18/2019 |
| Geschätztes primäres Abschlussdatum: | 11/30/2019 |
| Voraussichtliches Abschlussdatum der Studie: | 11/30/2019 |
Zustand oder Krankheit
Intervention / Behandlung
Dietary Supplement: Probiotics
Dietary Supplement: Placebo - No probiotics
Phase
Armgruppen
| Arm | Intervention / Behandlung |
|---|---|
| Active Comparator: Probiotics Participants will receive two lozenges containing probiotic bacteria and cranberry. | Dietary Supplement: Probiotics A half of the participants will be randomly allocated to the probiotics group. They will receive two probiotics lozenge before falling asleep for 8 weeks. Clinical examination will be conducted before study and after 8 weeks. |
| Placebo Comparator: Placebo - No probiotics Participants will receive a control two lozenges containing no probiotic bacteria. | Dietary Supplement: Placebo - No probiotics A half of the participants will be randomly allocated to the placebo group. They will receive two no probiotics lozenge before falling asleep for 8 weeks. Clinical examination will be conducted before study and after 8 weeks. |
Zulassungskriterien
| Altersberechtigt für das Studium | 3 Years Zu 3 Years |
| Studienberechtigte Geschlechter | All |
| Akzeptiert gesunde Freiwillige | Ja |
| Kriterien | Inclusion Criteria: - generally healthy children aged 3-6; - recognized caries of early childhood, dmf> 1, - lack of active caries and inflammation of the mouth - colony forming unit CFU > 105 / ml Streptococcus mutans - a minimum of one-month period from: the last antibiotic therapy, probiotic use, professional fluoride prophylaxis or supervised tooth brushing with fluoride preparations, the use of fluoride toothpaste, not using xylitol, written consent of parents / legal guardians for participation in research. Exclusion Criteria: - chronic diseases and chronically taken medicines in the past, - planned change of residence during the year, - age below 3 and above 6 years, - healthy teeth, dmf = 0, - colony forming unit CFU <105 / ml Streptococcus mutans - Patient during antibiotic therapy, probiotic use, professional fluoride prophylaxis or supervised tooth brushing with fluoride preparations - no toothpaste with fluoride - using xylitol - lack of written consent of parents / legal guardians for participation in research. |
Ergebnis
Primäre Ergebnismaße
1. Changing the titre of the carcinogenic bacteria Streptococcus mutans [8 weeks]
