Recurrent AA Amyloidosis After Renal Transplantation
Schlüsselwörter
Abstrakt
Beschreibung
AA amyloidosis is a rare but serious complication of several chronic inflammatory diseases including recurrent hereditary periodic fever syndromes. Although end-stage renal disease related to AA amyloidosis is well characterized, there is limited data concerning patient and graft outcomes after renal transplantation, with most of the findings reported from small series. Recurrence of amyloidosis in the renal allograft might be underdiagnosed, assessing graft and patient outcomes in larger study groups will bring better understanding and new strategies in daily practice.
Termine
| Zuletzt überprüft: | 03/31/2017 |
| Zuerst eingereicht: | 03/03/2016 |
| Geschätzte Einschreibung eingereicht: | 03/03/2016 |
| Zuerst veröffentlicht: | 03/08/2016 |
| Letztes eingereichtes Update: | 04/14/2017 |
| Letztes Update veröffentlicht: | 04/17/2017 |
| Tatsächliches Startdatum der Studie: | 01/31/2016 |
| Geschätztes primäres Abschlussdatum: | 09/30/2016 |
| Voraussichtliches Abschlussdatum der Studie: | 11/30/2016 |
Zustand oder Krankheit
Phase
Armgruppen
| Arm | Intervention / Behandlung |
|---|---|
| Recurrent AA amyloidosis Renal transplant recipients with biopsy-confirmed AA amyloidosis in the renal allograft | |
| Control group 1 Renal transplant recipients whose primary diseases are amyloidosis with no clinical or laboratory signs of recurrence in the renal allograft | |
| Control group 2 Renal transplant recipients whose primary diseases are other than amyloidosis |
Zulassungskriterien
| Altersberechtigt für das Studium | 18 Years Zu 18 Years |
| Studienberechtigte Geschlechter | All |
| Probenahmeverfahren | Non-Probability Sample |
| Akzeptiert gesunde Freiwillige | Ja |
| Kriterien | Inclusion Criteria: - Renal transplantation recipients whose primary renal disease is AA amyloidosis; patients with allograft biopsy-confirmed AA amyloidosis (for study group) and patients with no clinical or laboratory signs of recurrence in the renal allograft (for control group 1) - Renal transplantation recipients whose primary diseases are other than AA amyloidosis (for control group 2) Exclusion Criteria: - Patients who are unwilling or unable to consent |
Ergebnis
Primäre Ergebnismaße
1. Allograft survival [1 - 5 years]
Sekundäre Ergebnismaße
1. Allograft rejection [1 - 5 years]
