Effect of Mango on Gut Microbiota and Metabolic Health
Schlüsselwörter
Abstrakt
Termine
| Zuletzt überprüft: | 02/29/2020 |
| Zuerst eingereicht: | 01/21/2019 |
| Geschätzte Einschreibung eingereicht: | 01/28/2019 |
| Zuerst veröffentlicht: | 01/30/2019 |
| Letztes eingereichtes Update: | 03/23/2020 |
| Letztes Update veröffentlicht: | 03/24/2020 |
| Tatsächliches Startdatum der Studie: | 01/14/2019 |
| Geschätztes primäres Abschlussdatum: | 12/19/2019 |
| Voraussichtliches Abschlussdatum der Studie: | 11/30/2021 |
Zustand oder Krankheit
Intervention / Behandlung
Dietary Supplement: Mango consumption
Phase
Armgruppen
| Arm | Intervention / Behandlung |
|---|---|
| Experimental: Mango consumption | Dietary Supplement: Mango consumption Daily consumption of 280 g of frozen mangos during 8 weeks. The daily dose in equivalent to a 2-cups serving. |
Zulassungskriterien
| Altersberechtigt für das Studium | 18 Years Zu 18 Years |
| Studienberechtigte Geschlechter | All |
| Akzeptiert gesunde Freiwillige | Ja |
| Kriterien | Inclusion Criteria: - Healthy men and premenopausal women - Body mass index (BMI) ≥25 kg/m2 and ≤40 kg/m2 - Waist circumference ≥80 cm for women and ≥94 cm for men - Caucasian origin Exclusion Criteria: - Nicotine use - Metabolic disorders or use of medication that may affect parameters measured in the study - Use of dietary supplements or natural health product in the last 3 months - Use of antibiotics in the last 3 months - Surgery in the last 3 months or planned during the study timeline - Alcohol consumption >2 drinks/day - Weight change >5% in the last 3 months - Mango aversion, allergy or intolerance - Dietary restrictions (vegetarian, gluten avoidance...) - Berries consumption >1 serving/day - Pregnancy, breastfeeding or pregnancy planned within 3-6 months |
Ergebnis
Primäre Ergebnismaße
1. Changes in plasma insulin concentration of overweight/obese men and women taking frozen mangos daily [8 weeks]
2. Changes in plasma glucose concentration of overweight/obese men and women taking frozen mangos daily [8 weeks]
3. Changes in plasma triglycerides concentration of overweight/obese men and women taking frozen mangos daily [8 weeks]
4. Changes in plasma total cholesterol concentration of overweight/obese men and women taking frozen mangos daily [8 weeks]
5. Changes in plasma HDL cholesterol concentration of overweight/obese men and women taking frozen mangos daily [8 weeks]
6. Changes in plasma LDL cholesterol concentration of overweight/obese men and women taking frozen mangos daily [8 weeks]
Sekundäre Ergebnismaße
1. Changes in waist circumference of overweight/obese men and women taking frozen mangos daily [8 weeks]
2. Changes in hip circumference of overweight/obese men and women taking frozen mangos daily [8 weeks]
3. Changes in waist to hip circumference ratio of overweight/obese men and women taking frozen mangos daily [8 weeks]
4. Height of overweight/obese men and women taking frozen mangos daily [Baseline]
5. Changes in weight of overweight/obese men and women taking frozen mangos daily [8 weeks]
6. Changes in body mass index (BMI) of overweight/obese men and women taking frozen mangos daily [8 weeks]
7. Changes in systolic blood pressure of overweight/obese men and women taking frozen mangos daily [8 weeks]
8. Changes in diastolic blood pressure of overweight/obese men and women taking frozen mangos daily [8 weeks]
9. Changes in insulin secretion of overweight/obese men and women taking frozen mangos daily [8 weeks]
10. Changes in insulin sensitivity of overweight/obese men and women taking frozen mangos daily [8 weeks]
11. Changes in glycated hemoglobin (HbA1c) in overweight/obese men and women taking frozen mangos daily [8 weeks]
12. Changes in plasma tumor necrosis factor (TNF-alpha) concentration of overweight/obese men and women taking frozen mangos daily [8 weeks]
13. Changes in plasma interleukin-6 (IL-6) concentration of overweight/obese men and women taking frozen mangos daily [8 weeks]
14. Changes in plasma high-sensitivity C-reactive protein (hs-CRP) concentration of overweight/obese men and women taking frozen mangos daily [8 weeks]
15. Changes in gene expression in peripheral blood mononuclear cells (PBMC) of overweight/obese men and women taking frozen mangos daily [8 weeks]
16. Changes in plasma metabolites concentration in overweight/obese men and women taking frozen mangos daily [8 weeks]
17. Changes in gut microbiota composition in overweight/obese men and women taking frozen mangos daily [8 weeks]
18. Changes in plasma lipopolysaccharide (LPS) concentration of overweight/obese men and women taking frozen mangos daily [8 weeks]
19. Changes in plasma LPS binding protein (LBP) concentration of overweight/obese men and women taking frozen mangos daily [8 weeks]
