Effectiveness Fluoride Varnishes in Children With Early Childhood Caries
Schlüsselwörter
Abstrakt
Beschreibung
Duraphat (Colgate), which we used as a positive control group in our study, contains only 5% sodium fluoride. It has been reported in studies that Duraphat is effective in remineralization.
Clinpro ™ White Varnish, another topical varnish in this study,was reported to be effective for caries prevention in pre-school children.
One of the varnishes we evaluate in the study, Embrace™ Varnish, contains 5% sodium fluoride with xylitol-coated calcium and phosphate. According to the manufacturer, the xylitol coating prevents the calcium and phosphate salts from reacting until they come in contact with saliva. Saliva dissolves the xylitol and releases the calcium and phosphate ions, which react with the fluoride ions in saliva to form protective fluorapatite on the teeth19 MI Varnish, in the fourth group containing 5% sodium fluoride with casein phosphopeptide amorphous calcium phosphate (CPP-ACP) had a high release of calcium and fluoride ions.
Termine
| Zuletzt überprüft: | 07/31/2018 |
| Zuerst eingereicht: | 07/26/2018 |
| Geschätzte Einschreibung eingereicht: | 08/08/2018 |
| Zuerst veröffentlicht: | 08/09/2018 |
| Letztes eingereichtes Update: | 08/08/2018 |
| Letztes Update veröffentlicht: | 08/09/2018 |
| Tatsächliches Startdatum der Studie: | 10/31/2016 |
| Geschätztes primäres Abschlussdatum: | 06/30/2017 |
| Voraussichtliches Abschlussdatum der Studie: | 11/30/2017 |
Zustand oder Krankheit
Intervention / Behandlung
Drug: Sodium Fluoride
Drug: Sodium Fluoride with TCP
Drug: Sodium Fluoride with CXP
Drug: Sodium Fluoride with CPP-ACP
Phase
Armgruppen
| Arm | Intervention / Behandlung |
|---|---|
| Active Comparator: Sodium Fluoride Varnish containing 5% Sodium Fluoride, was applied to all remaining teeth of each child after dental treatment under general anaesthesia. | Drug: Sodium Fluoride |
| Experimental: Sodium Fluoride with TCP Varnish containing 5% Sodium Fluoride with tricalcium phosphate (TCP) ,varnish was applied to all remaining teeth of each child after dental treatment under general anaesthesia. | Drug: Sodium Fluoride with TCP |
| Experimental: Sodium Fluoride with CXP Varnish containing 5% Sodium Fluoride with Xylitol-coated Calcium and Phosphate (CXP) ,varnish was applied to all remaining teeth of each child after dental treatment under general anaesthesia. | Drug: Sodium Fluoride with CXP |
| Experimental: Sodium Fluoride with CPP-ACP Varnish containing 5% Sodium Fluoride with casein phosphopeptide amorphous calcium phosphate (CPP-ACP), varnish was applied to all remaining teeth of each child after dental treatment under general anaesthesia. | Drug: Sodium Fluoride with CPP-ACP |
Zulassungskriterien
| Altersberechtigt für das Studium | 36 Months Zu 36 Months |
| Studienberechtigte Geschlechter | All |
| Akzeptiert gesunde Freiwillige | Ja |
| Kriterien | Inclusion Criteria: - clinical diagnosis of healthy children with severe early childhood caries, - younger than 6 years in the primary dentition Exclusion Criteria: - history of any chronic disease, - use of any drugs that reduce salivary flow or antibiotics in the last 4 weeks, - use of systemic fluoride tablets |
Ergebnis
Primäre Ergebnismaße
1. Effect of fluoride varnishes on saliva Mutans streptococci (MS) and Lactobacilli (LB) levels were evaluated as colony forming units (CFU). [3 months]
