Evaluation of Melatonin Application of Immediate Dental Implant
Schlüsselwörter
Abstrakt
Beschreibung
Melatonin is chemically recognized as N-acetyl-5-methoxytryptamine. It is a compound occurring naturally in plants, microbes and animals. The circulating level of the melatonin hormone in animals shows interesting variations, by entertainment of variable biological functions in a daily cycle "circadian rhythm". Melatonin called hormone of night is secreted by the pineal gland, and its plasma levels concentration are 50 folds higher in night in comparison to daytime. A variety of peripheral cells play a role in production of melatonin such as epithelial cells, bone marrow cells, and lymphocytes. Though melatonin is a hormone, it does not act on a specific organ, it has several functions; stimulation of the synthesis of type I collagen fibers, regulation of the body temperature, sexual development, antioxidant scavenging and detoxifying free radicals thus inhibiting the process of bone resorption through interfering with the function of osteoclasts.
Termine
Zuletzt überprüft: | 12/31/2019 |
Zuerst eingereicht: | 09/25/2018 |
Geschätzte Einschreibung eingereicht: | 09/26/2018 |
Zuerst veröffentlicht: | 09/30/2018 |
Letztes eingereichtes Update: | 01/25/2020 |
Letztes Update veröffentlicht: | 01/27/2020 |
Tatsächliches Startdatum der Studie: | 09/29/2019 |
Geschätztes primäres Abschlussdatum: | 09/29/2020 |
Voraussichtliches Abschlussdatum der Studie: | 12/29/2020 |
Zustand oder Krankheit
Intervention / Behandlung
Device: immediate implant placement
Drug: implant placement with melatonine
Phase
Armgruppen
Arm | Intervention / Behandlung |
---|---|
Experimental: implant placement with melatonine immediate implant placement with melatonine | Drug: implant placement with melatonine topical application of melatonin |
Active Comparator: immediate implant placement alone immediate implant placement alone |
Zulassungskriterien
Altersberechtigt für das Studium | 18 Years Zu 18 Years |
Studienberechtigte Geschlechter | All |
Akzeptiert gesunde Freiwillige | Ja |
Kriterien | Inclusion criteria 1. Age: 18-60. 2. Healthy patients 3. Non Smoker 4. Patients with adequate bone volume for immediate dental implant procedure. 5. Patients with absence of any periapical pathosis. Exclusion criteria: 1. Heavy smokers. 2. Systemic disease that contraindicates implant placement or surgical procedures. 3. No or poor patient's compliance. 4. Psychological problems. 5. Pathology at the site of intervention. 6. Pregnancy females. 7. Patient refuses to sign the informed consent. |
Ergebnis
Primäre Ergebnismaße
1. implant stability [6 months]
Sekundäre Ergebnismaße
1. Soft tissue healing [10 days]
2. Post operative pain [10 days]