[Protective effect of hyperin on cerebral infarction in rats].

OBJECTIVE

To study the protective effect of hyperin (Hyp) on cerebral infarction.

METHODS

The cerebral infarction in rats was made by ligating the right common carotid artery and the right middle cerebral artery. The infarction weight was determined by NBT stain. The cerebral cortex was taken to measure nitric oxide (NO) and malondialdehyde (MDA). The cerebral blood flow(CBF) was measured with H2 clearance method.

RESULTS

Hyp 6.25, 12.5, 25 mg.kg-1 markedly improved the abnormal nervous symptoms, and 12.5, 25 mg.kg-1 Hyp significantly reduced the infarction weight and inhibited the increase of MDA and NO in the cerebral cortex. Hyp(25, 12.5 mg.kg-1) could increase the CBF of the cerebral cortex.

CONCLUSIONS

Hyp has a protective effect on cerebral infarction via attenuating lipid peroxidation and NO.