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angiofibroma/progesterone
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[Value of free testosterone and estrogen-progesterone receptor concentration in juvenile patients with angiofibroma].
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The same localisation, age and sex patients at juvenile nasopharyngeal angiofibroma may suggest relation its pathogenesis to hormonal changes of pubertal period. The examined group comprised 3 juvenile nasopharyngeal angiofibroma patients treated in ENT Clinic of K. Marcinkowski University of
Vascular solitary fibrous tumor with "floret" cells or giant cell angiofibroma? A lingual example highlighting the overlapping characteristics of these entities and positive immunoreaction for estrogen and progesterone receptors.
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Recent literature suggests that giant cell angiofibroma (GCAF) is a variant of solitary fibrous tumor (SFT) and not just a related lesion. Herein we present a case of apparent SFT with giant cells, including floret cells and focal pseudovascular areas, which are defining features of GCAF. The tumor
Hormonal receptor determination in juvenile nasopharyngeal angiofibromas.
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Juvenile nasopharyngeal angiofibromas (JNA) are rare. They have been frequently treated with estrogens, either solely or as an adjuvant therapy prior to surgery or irradiation. Clinical trials have proveded no evidence to explain the objective respose to estrogens observed in some tumors. Since the
Immunohistochemical analysis of steroid hormone receptors in nasopharyngeal angiofibromas.
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Juvenile nasopharyngeal angiofibroma arises almost exclusively in pubertal and adolescent men and has potentially aggressive behavior with a spread into adjoining sinuses and bone destruction. It is classically being regarded as an androgen hormone-dependent tumor, but no in situ evaluation of
Histological spectrum of angiofibroma of soft tissue: histological and genetic analysis of 13 cases.
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OBJECTIVE
Angiofibroma of soft tissue (AFST) is a rare soft tissue neoplasm characterized by a fibroblastic cytomorphology and a prominent vascular structure. AFSTs possess a novel fusion gene, i.e. NCOA2-AHRR/AHRR-NCOA2 or GTF2I-NCOA2, providing a useful approach to diagnosing AFST.
Diagnostic utility of NCOA2 fluorescence in situ hybridization and Stat6 immunohistochemistry staining for soft tissue angiofibroma and morphologically similar fibrovascular tumors.
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Soft tissue angiofibroma (STA), a recently suggested new histologic entity, is a benign fibrovascular soft tissue tumor composed of bland spindle-shaped tumor cells with abundant collagenous to myxoid stroma and branching small vessels. The lesion has a characteristic AHRR-NCOA2 fusion gene derived
Juvenile angiofibromas: a 40-year surgical experience.
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A series of 22 patients with histologically confirmed angiofibroma were treated primarily by surgical removal at the University of Freiburg ENT clinic during the 40-year period, 1946-1986. These tumors were staged according to size and extension on the basis of roentgenographic and surgical
Expression of androgen receptors in nasopharyngeal angiofibroma: an immunohistochemical study of 24 cases.
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Angiofibromas are uncommon benign tumors that typically occur in the lateral portion of the nasopharynx of adolescent boys. Numerous reports showed indirect evidence for the presence of sex-hormone receptors, i.e., androgen (AR), estrogen (ER), and progesterone (PR) receptors, in these tumors. The
Diagnosis, staging, and treatment of juvenile nasopharyngeal angiofibroma (JNA).
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Nineteen patients with juvenile nasopharyngeal angiofibroma (JNA) were surgically treated with different techniques from January 1968 through December 1985. Two patients had undergone a previous operation at another hospital; all patients were males (mean age 15.4), and the most common symptom was
Multiple steroid receptors in nasopharyngeal angiofibromas.
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Cytosols from 12 nasopharyngeal angiofibroma tissues were analyzed for the presence of estrogen (ER), progesterone (PR), androgen (AR), and glucocorticoid (GR) receptors, by using a dextran charcoal assay. Progesterone receptors (58%) clearly predominate over ER and AR (25%). Thus, nasoangiofibromas
Sex hormones in juvenile nasopharyngeal angiofibroma tissue.
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Five cases of juvenile nasopharyngeal angiofibroma were studied in terms of the presence of progesterone, estradiol, testosterone, and dihydrotestosterone in the juvenile nasopharyngeal angiofibroma tissue using the peroxidase-antiperoxidase method. Progesterone and estradiol were positive in all
Steroid hormone receptor expression in nasopharyngeal angiofibromas. Consistent expression of estrogen receptor beta.
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Nasopharyngeal angiofibroma is an uncommon tumor arising in adolescent males, suggesting that the tumor may be hormonally responsive. Previous studies have found androgen receptor (AR) expression but variable expression of estrogen receptor (ER). The recently described ss receptor for estrogen has
Expression of sex hormone receptors in juvenile angiofibromas and antiproliferative effects of receptor modulators.
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BACKGROUND
Predilection of juvenile angiofibromas in adolescent boys has prompted the hypothesis of hormone-dependent tumor growth. However, knowledge on expression and function of sex hormone receptors in juvenile angiofibromas is still sparse and inconsistent.
METHODS
Transcript and protein
Estimation of oestrogen and progesterone receptors in chronic rhinitis.
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The turbinates of 38 patients with chronic rhinitis were examined biochemically for oestrogen and progesterone receptors. Low levels of oestrogen-receptor-like activity (1-20 fmol/mg protein) were found in 50% of patients of both sexes. Progesterone receptor activity was also weak (1-16 fmol/mg
Cellular angiofibroma of the vulva: a clinicopathological study of two cases with documentation of some unusual features and review of the literature.
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BACKGROUND
Cellular angiofibroma (CA) of the vulva is a recently described condition, whose clinical and pathological features are poorly known.
METHODS
We have encountered two cases of this very unusual tumor. Their clinical and pathological features were analyzed and compared to those reported in
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