After randomization healthy volunteers or patients with idiopathic generalized epilepsy receive:
-sequence A: 1 mg/kg and then 5 mg/kg of apomorphine

After randomization healthy volunteers or patients with idiopathic generalized epilepsy receive:
sequence B: 2 injections of saline

Idiopathic Generalized Epilepsy

Dosage Form: Injection Dosage: 1 or 5 mg / kg
Route of administration: Subcutaneous
Duration of treatment: two injections of apomorphine followed by two injections of a placebo one week after or vice versa.
Two injections will be made by visiting during visits 2 and 3.
The study was conducted cross-over with two visits EEG recording, the order will be randomized injections:
Sequence A during visit 2 followed by sequence B during visit 3
or sequence B during visit 2

Apomorphine (Experimental product)

CIC Department - University Hospital of Grenoble

Blinking and Yawning in Epilepsy: The Role of Dopamine

Dopaminergic Reactivity In Idiopathic Generalized Epilepsy: A "Proof Of Concept" Clinical, Pharmacological And Neurophysiological Study

Number of yawn at 60 minuts after the injection of apomorphine in patients with idiopathic generalized epilepsy compared to healthy volunteers.

Number of eyelid Blinking at 60 minuts after the injection of apomorphine in patients with idiopathic generalized epilepsy compared to healthy volunteers.

Evolution of yawn number between base line period and the 60 minuts following the injection of apomorphine in patients with idiopathic generalized epilepsy compared to healthy volunteers matched.

The number of eyelid blinking after apomorphin or placebo injection is compare in both groups

Number and cumulated duration of Spike-waves discharge assessed after injection of apomorphine in patients with idiopathic generalized epilepsy

Correlation between yawning/blinking and the number of Spike-wave discharges in patients with epilepsy (Pearson test)

Comparison between plasma concentrations of prolactin and growth hormone (GH) in patients and controls after injection of apomorphine or placebo.

This is a descriptive outcome. The number of each adverse event occured at 4 weeks will be listed

apomorphine/epileptischer anfall

Blinking and Yawning in Epilepsy: The Role of Dopamine

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