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The use of atropine has emerged over the past few years as a treatment for asthma. Scopolamine is pharmacologically similar to atropine and, as such, was used in a study of nine patients as a bronchodilator. These nine patients had diverse types of lung diseases. Two patients were intolerant to the
Codonopsis lanceolata (Campanulaceae) have been traditionally used to treat lung inflammatory diseases, such as asthma, tonsillitis, and pharyngitis. The present study was performed to evaluate the cognitive-enhancing effects of steamed and fermented C. lanceolata in scopolamine-induced memory
Anticholinergic agents have been widely used in the management of asthma. The use of scopolamine has been limited by significant side effects. Transdermal delivery of scopolamine (TS) has, however, been used successfully for the prevention of motion sickness. The purpose of this study was to
Oxitropium bromide is a derivative of scopolamine and is an anticholinergic drug. Twenty asthmatics completed the study in which they received, in randomised double-blind fashion, placebo, ipratropium bromide 80 micrograms, and oxitropium bromide 200 micrograms. The patients recorded peak expiratory
Southern Africa has a variety of medicinal plants, used as remedies; however, little information is available regarding the cytotoxic potential, particularly when used during pregnancy. One such plant is Datura stramonium (DS) (Solanaceae), used frequently as an anti-asmatic treatment. DS contains a
BACKGROUND
Gynostemma pentaphyllum (Thunb.) Makino (GP, family Cucurbitaceae), which contains dammarane saponins as its main constituents, is used in China, Japan, and Korea as a traditional medicine to treat cancer, obesity, arteriosclerosis, asthma and senility.
OBJECTIVE
To investigate the
This paper reviews briefly the place of ipratropium bromide in the treatment of airways obstruction. Oxitropium bromide, a new quaternary ammonium compound derived from scopolamine was shown to be as effective a bronchodilator in a dose of 200 micrograms by inhalation as ipratropium bromide 80
The aim of the current study was to characterize comparatively the binding of muscarinic receptor in the lung of rats intratracheally administered anticholinergic agents (tiotropium, ipratropium, glycopyrrolate) used clinically to treat chronic obstructive pulmonary disease (COPD) and asthma.
Serious poisoning may occur following the consumption of Chinese herbal medicines (CHM) containing anticholinergics. The great majority of cases are probably related to the use of yangjinhua, the dried flower of Datura metel L, for treating bronchial asthma, chronic bronchitis, pains and flu
The stable, transparent, thermoreversible organogels which are prepared by adding a minute amount of water to a solution of lecithin in isopropylpalmitate are studied as matrices for promoting the transdermal transport of drugs throughout the skin. In this work we study this process by using two
The effect of oxitropium bromide (Ba253), a quaternary scopolamine derivative, on the resting tonus and agonist-induced contraction of isolated guinea pig airway smooth muscle and on the anaphylactic release of histamine and immunoreactive leukotrienes (i-LTs) from lung fragments were investigated
A change in muscarinic receptor-induced phosphoinositide (PI) metabolism or inhibition of adenylyl cyclase activity could play a role in cholinergic hyperresponsiveness in patients with asthma. In the present study, we considered the possibility of using peripheral blood lymphocytes or
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by memory impairment. Codonopsis lanceolata (C. lanceolata) has been employed clinically for lung inflammatory diseases such as asthma, tonsillitis, and pharyngitis. The present study was undertaken to evaluate the
BACKGROUND
Robotic assisted laparoscopic radical prostatectomy (RALP) is a common treatment for localized prostate cancer. Despite a primary advantage of improved postoperative pain, patients undergoing RALP still experience discomfort. Belladonna, containing the muscarinic receptor antagonists