one portion (300 g each) per week of a soup containing standard broccoli

one portion (300 g each) per week of a soup containing glucoraphanin-enriched broccoli named for the study 'Beneforte extra'

Prostate Cancer

300g/week of standard broccoli soup consumed for a period of six months delivering standard level of glucoraphanin (sulforaphane precursor)

Standard broccoli soup

300g/week of beneforte extra broccoli soup consumed for a period of six months delivering enriched levels of glucoraphanin (sulforaphane precursor)

Beneforte extra broccoli soup

Cambridge University Hospitals NHS Foundation Trust_Addenbrooke's Hospital

Utilizing MRI to Study the Effect of Sulforaphane on Prostate Cancer

Effect of Sulforaphane on Prostate CAncer PrEvention-imagING Evaluation

change in prostate tumor/blood flow size determined by MRI methods within the prostate gland

concentration of metabolites (choline + creatine/citrate ratio) in the prostate tissue determined by using MR spectroscopy

concentration of citrate and associated metabolites in body fluids (blood, urine)

plasma levels of prostate-specific antigen (PSA) and other blood markers

Glutathione S-transferase Mu 1 (GSTM1) genotype or other relevant genotypes on mediating metabolite changes by diet

Quadram Institute Bioscience

Cambridge University Hospitals NHS Foundation Trust

This is a randomized, double-blinded, three-phase crossover trial investigating the bioavailability of SF following consumption of three types of broccoli + stilton soup containing different concentrations of glucoraphanin. The three types of soup are standard broccoli and stilton soup, beneforte broccoli and stilton soup, and beneforte extra broccoli and stilton soup.

Healthy

Participants will be randomised to eat one portion (300g) of broccoli soup for each phase.

Standard broccoli and stilton soup

Beneforte broccoli and stilton soup

Beneforte Extra broccoli and stilton soup

Institute of Food Research

The Bioavailability Of Sulforaphane From Broccoli Soups Study (BOBS)

An Intervention Study to Assess the Bioavailability of Sulforaphane Delivered by Glucoraphanin-enriched Broccoli Soups in Healthy Subjects

To measure the total excretion of SF in urine collected for 24 hours after consumption of one pot (300g) of three types of broccoli + stilton soup containing different concentrations of glucoraphanin, SF precursor.

• To measure SF and its metabolites in plasma following consumption of one pot (300g) of three types of broccoli + stilton soup containing different concentrations of glucoraphanin.

Biotechnology and Biological Sciences Research Council

Prostate Cancer Foundation

Subjects with proliferative thyroid disease

Proliferative Thyroid Disease

300 mg of Bioresponse DIM (100mg/day of active DIM) a day for 30 days

Diindolylmethane (DIM)

The New York Eye & Ear Infirmary

DIM as a Treatment for Thyroid Disease

Diindolymethane: Anti-proliferation Agent in Thyroid Disease-Non-surgical Protocol

Stimpson P. Schantz

Principal Investigator

A healthy Nordic diet with high content of bitter strong tasting vegetables and cabbages.

A diet habitually consumed in the Nordic countries

A healthy Nordic diet with high content of sweet and mild tasting vegetables and cabbages.

Type 2 Diabetes

The participants in the two experimental arms will each have to consume 500 g of vegetables and cabbages daily.

Diet intervention

Click here for more information about this study: Maximising the Taste and Health Value of Plant Food Products (MAXVEG)

Hospital Vendsyssel, Center for Clinical Research

Maximising the Taste and Health Value of Plant Food Products

Maximising the Taste and Health Value of Plant Food Products - Impact on Vegetable Consumption, Consumer Preferences and Human Health Factors.

Measured as the AUC from an Oral Glucose Tolerance Test

The fasting blood samples will be analyzed for: glucose, insulin, glucagon, HbA1c, lipids (triglycerides, HDL-, LDL- and total cholesterol), cytokines (, adipokines biomarkers of oxidative stress parathyroid hormone, vitamin D and GLP-1.
Urine samples for metabolomics (isoprostanes and water-soluble metabolites).

brassica fruticulosa/Antikrebs

Utilizing MRI to Study the Effect of Sulforaphane on Prostate Cancer

The Bioavailability Of Sulforaphane From Broccoli Soups Study (BOBS)

DIM as a Treatment for Thyroid Disease

Maximising the Taste and Health Value of Plant Food Products

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