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daidzein/zahnkaries

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Spectroscopy and molecular docking study on the interaction of daidzein and genistein with pepsin.

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The interaction of pepsin with daidzein (Dai) or genistein (Gen) was investigated using spectroscopic techniques under simulated physiological conditions. Dai and Gen can quench the fluorescence of pepsin and the quenching mechanism was a static process. The binding site number n and apparent

Contrasting binding of fisetin and daidzein in γ-cyclodextrin nanocavity.

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Steady state and time resolved fluorescence along with anisotropy and induced circular dichroism (ICD) spectroscopy provide useful tools to observe and understand the behavior of the therapeutically important plant flavonoids fisetin and daidzein in γ-cyclodextrin (γ-CDx) nanocavity.

Inhibitory effects of daidzein and genistein on trypsin: Insights from spectroscopic and molecular docking studies.

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In this work, the inhibitory effect of two isoflavonoids including daidzein and genistein on trypsin and their binding mechanism were determined by spectroscopic and molecular docking approaches. The results indicated that both daidzein and genistein reversibly inhibited trypsin in a competitive

Differentiation of promyelocytic leukemia cells HL-60 induced by daidzein in vitro and in vivo.

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We have screened more than one thousand synthetic and natural chemicals to explore differentiation inducers and found that daidzein has potent differentiation-inducing activity for human leukemia HL-60 cells, both in vitro and in vivo. In vitro study showed that daidzein at concentrations exceeding

Inclusion complexes of phosphorylated daidzein derivatives with β-cyclodextrin: Preparation and inclusion behavior study.

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In the present work the feasibility of β-cyclodextrin in complexation was explored, as a tool for improving the solubility and biological ability of daidzein derivatives. A series of phosphorylated daidzein derivatives featuring different chain lengths were synthesized through a modified

Protective effects of sodium daidzein sulfonate on trabecular bone in ovariectomized rats.

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The ovariectomized (OVX) rat, as an established animal model of human osteoporosis, was adopted in the present experiment to study the protective effects of sodium daidzein sulfonate (SDS) on trabecular bone. Six-month-old Sprague-Dawley rats were sham-operated or ovariectomized. Five days later,

[Preventive effect of daidzein on testosterone-induced prostatic hyperplasia in rats].

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OBJECTIVE To investigate the preventive effect of the phytoestrogen daidzein on prostatic hyperplasia induced by testosterone in rats. METHODS Thirty-six male adult Sprague-Dawley rats were equally randomized into 6 groups: Group I and II (normal control and model, treated with 1 ml distilled water

Evaluation of daidzein-loaded chitosan microspheres in vivo after intramuscular injection in rats.

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Daidzein-loaded chitosan microspheres were prepared by emulsification/chemical-crosslinking technique. The dialysis bag method determined the release of daidzein from the microspheres. It demonstrated that the accumulative release curve in vitro was fit for the zero-order release equation and had

Mechanical and aesthetics compatibility of Brazilian red propolis micellar nanocomposite as a cavity cleaning agent.

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BACKGROUND Propolis is a natural substance produced by bees and is known to have antimicrobial activity. Our aim was to evaluate the antimicrobial effect of micellar nanocomposites loaded with an ethyl acetate extract of Brazilian red propolis as a cavity cleaning agent and its influence on the

Daidzein/cyclodextrin/hydrophilic polymer ternary systems.

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OBJECTIVE To evaluate the effect of different cyclodextrins (β-cyclodextrin [β-CD], methyl-β-cyclodextrin [Mβ-CD], or hydroxypropyl-β-cyclodextrin [HPβ-CD]) and/or hydrophilic polymers (carboxymethylcellulose, hydroxypropylmethylcellulose [HPMC], polyethyleneglycol, or polyvinylpyrrolidone [PVP]) on

Studies on the Inclusion Complexes of Daidzein with β-Cyclodextrin and Derivatives.

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The inclusion complexes between daidzein and three cyclodextrins (CDs), namely β-cyclodextrin (β-CD), methyl-β-cyclodextrin (Me-β-CD, DS = 12.5) and (2-hydroxy)propyl-β-cyclodextrin (HP-β-CD, DS = 4.2) were prepared. The effects of the inclusion behavior of daidzein with three kinds of cyclodextrins

Multiple complexation of cyclodextrin with soy isoflavones present in an enriched fraction.

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In the present study we evaluated the complexation of daidzein/genistein/glycitein, present in an isoflavone enriched fraction (IEF), with β-cyclodextrin and 2-hydroxypropyl-β-cyclodextrin (HPβCD). Based on the increased solubility and higher complexation efficiency, IEF and HPβCD solid complexes

Comparative studies on the interaction of nine flavonoids with trypsin

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In this study, the interaction between nine classic flavonoids (including baicalin, quercetin, myricetin, rutin, puerarin, daidzein, liquiritin and isoliquiritin) and trypsin was investigated by fluorescence spectroscopy and molecular modeling methods. The results reveal that all flavonoids can

Effects of dietary phytoestrogens on plasma testosterone and triiodothyronine (T3) levels in male goat kids.

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BACKGROUND Exposure to xenoestrogens in humans and animals has gained increasing attention due to the effects of these compounds on reproduction. The present study was undertaken to investigate the influence of low-dose dietary phytoestrogen exposure, i.e. a mixture of genistein, daidzein, biochanin

Flavonoids induce temporal shifts in gene-expression of nod-box controlled loci in Rhizobium sp. NGR234.

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Rhizobia, soil bacteria of the Rhizobiales, enter the roots of homologous legumes, where they induce the formation of nitrogen-fixing nodules. Signals emanating from both symbiotic partners control nodule development. Efficient nodulation requires precise, temporal regulation of symbiotic genes.
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