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gallstones/adipositas
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12 Ergebnisse
Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
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The contents of the text file named SYPA-003_C04US_SeqList_ST25.txt, which was created on Jun. 17, 2015 and is 107 KB in size, are hereby incorporated by reference in their entirety.
FIELD OF THE INVENTION
The present invention relates to the therapeutic use of guanylate cyclase C (GC-C) agonists as
Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
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FIELD OF THE INVENTION
The present invention relates to the therapeutic use of guanylate cyclase C (GC-C) agonists as for reducing absorption of fat, triglycerides, bile acids and cholesterol. The agonists may be used either alone or in combination with inhibitors of cholesterol biosynthesis in the
Treatment of gallstones
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THIS INVENTION RELATES TO A METHOD OF TREATING GALLSTONES.
According to the present invention there is provided a method of treating gallstones, in which a therapeutically effective amount of a compound of formula I ##STR2##
including enantiomers and pharmaceutically acceptable salts thereof, in
Phenylaminoalkylcarboxylic acid derivatives and pharmaceutical compositions comprising the same
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TECHNICAL FIELD
The present invention relates to novel phenylaminoalkyl-carboxylic acid derivatives and pharmaceutically acceptable salts thereof which are useful as medicaments.
BACKGROUND ART
It is known that three subtypes of sympathomimetic .beta.-adrenoceptors, which have been classified as
Indazole compounds
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TECHNICAL FIELD
The present invention relates to indazole compounds having a .beta.3 adrenergic receptor agonist activity, a pharmaceutical composition containing the same, and uses of the compounds and the composition.
BACKGROUND ART
Noradrenaline and adrenaline are known to exhibit a variety of
Use of ivermectin and derivatives thereof
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CROSS-REFERENCE TO RELATED APPLICATIONS
This application is a National Stage filing under 35 U.S.C. .sctn. 371 of International Patent Application No. PCT/CN2013/077796, filed on Jun. 24, 2013, entitled "Use of Ivermectin and Derivatives Thereof", which claims the benefit of and priority to Chinese
2-methylpropionic acid derivatives and pharmaceutical compositions comprising the same
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TECHNICAL FIELD
The present invention relates to novel 2-methylpropionic acid derivatives and pharmaceutically acceptable salts thereof which are useful as medicaments.
BACKGROUND ART
It is known that three subtypes of sympathetic .beta.-adrenoceptors, which have been classified as .beta..sub.1,
2-Methylpropionic acid derivatives and medicinal compositions containing the same
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TECHNICAL FIELD
The present invention relates to novel 2-methylpropionic acid derivatives and pharmaceutically acceptable salts thereof which are useful as medicaments.
BACKGROUND ART
It is known that three subtypes of sympathetic .beta.-adrenoceptors, which have been classified as .beta..sub.1,
Phenoxyacetic acid derivatives and medicinal compositions containing the same
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TECHNICAL FIELD
The present invention relates to novel phenoxyacetic acid derivatives and pharmaceutically acceptable salts thereof which are useful as medicaments.
BACKGROUND ART
It is known that three subtypes of sympathetic .beta.-adrenoceptor, which have been classified as .beta..sub.1,
Mnk kinase homologous proteins involved in the regulation of energy homeostasis and organelle metabolism
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DESCRIPTION
This invention relates to the use of nucleic acid sequences of the MAP kinase-interacting kinase (Mnk) gene family and amino acid sequences encoded thereby, and to the use of these sequences or effectors of Mnk nucleic acids or polypeptides, particularly Mnk kinase inhibitors and
Protein disulfide isomerase and ABC transporter homologous proteins involved in the regulation of energy homeostasis
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CROSS-REFERENCE TO RELATED APPLICATIONS
This application claims priority to PCT Patent Application No. PCT/EP02/03540 filed Mar. 28, 2002 and European Patent Applications No. EP01 108 315.1 filed Apr. 2, 2001 and EP01 113 419.4 filed Jun. 1, 2001.
DESCRIPTION
This invention relates to the use of
Protein disulfide isomerase and ABC transporter homologous proteins involved in the regulation of energy homeostasis
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DESCRIPTION
This invention relates to the use of nucleic acid and amino acid sequences of protein disulfide isomerase and ABC transporter homologous proteins, and to the use of these sequences in the diagnosis, study, prevention, and treatment of diseases and disorders related to body-weight
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