Echo-guided bilateral subcostalTAP block will be performed using levobupivacaine [Chirocaine®] 0.375% Epi 1/200000.

Echo-guided bilateral subcostal TAP block will be performed with saline Epi 1/200000 in the control group.

Laparoscopic Cholecystectomy

Postoperative Analgesia

Echo-guided infiltration of a local anesthetic solution in the plane located between the transversus abdominis muscle and the rectus abdominis muscle

Bilateral subcostal TAP block

CHU Liege,

Analgesic Effect of TAP Block After Laparoscopic Cholecystectomy

Placebo-controlled, Randomized, Double-blind Trial of Transversus Abdominis Plane Block on Pain After Laparoscopic Cholecystectomy

opioid given as an IV titration in the PACU, and opioid po on the ward

postoperative pain will be separated out in parietal, visceral, and shouldertip pain; pain will be measured on 0-10 visual analog scale

PONV measured on 0-10 visual analog scale

end-tidal sevoflurane concentration will be recorded

Jean François Brichant

Head of the department of Anesthesiology

University of Liege

two groups : treatment group (TAP block with local anesthestic) compared to control group (TAP block with saline)

Person who prepares the study solution is involved neither in any step of the care of the patient neither in the collection of the study parameters

10 patients with hemochromatosis treated with Deferasirox

10 patients with hemochromatosis treated with venesection

20 patients with myelodysplastic syndrome treated with Deferasirox

10 healthy control persons to assess the normal level of investigational blood tests.

Hemochromatosis

Myelodysplastic Syndromes

Deferasirox tablets ( 250 mg or 500 mg) dispersed in a drinkable solution, 10 mg/kg/day, once daily for 12 months

Deferasirox

Treated with venesection every 8-10 day for 12 months, or until serum-ferritin has been reduced to about 50 µg/L.

Venesection

Deferasirox tablets ( 250 mg or 500 mg) dispersed in a drinkable solution starting with 10 mg/kg/day, once daily for 2 weeks and thereafter 20 mg/kg/day for 11,5 months.

Haukeland University Hospital, Clinical Trial Unit

Treatment of Iron Overload With Deferasirox (Exjade) in Hereditary Hemochromatosis and Myelodysplastic Syndrome

Deferasirox Versus Venesection in Patients With Hemochromatosis and for Treatment of Transfusional Siderosis in Myelodysplastic Syndrome: Diagnostics and New Biomarkers.

Cu,Zn-Super Oxid Dismutase (SOD)is an antioxidant enzyme

Haukeland University Hospital

Novartis

Participants randomized to TV NOTES cholecystectomy

Participants randomized to laparoscopic cholecystectomy

Cholecystolithiasis

Surgery

Pain

TV NOTES cholecystectomy

Departement of Surgical Gastroenterology, Gentofte Hospital

The Effect of Transvaginal vs. Conventional Laparoscopic Cholecystectomy on the Postoperative Course

Postoperative pain will be measured with VAS, 3 hours after the operation as well as on the first, second and third postoperative day. Pain score will be assessed at rest and during mobilization from supine to erect posture. Based on these assesments a cumulated overall pain score for the first 72 postoperative hours will be calculated by adding the respective scores for each participant.

Postoperative fatigue will be measured on a scale from 0 (no fatigue) to 10 (severe fatigue) 3 hours post surgery and on postoperative day 1, 2 and 3.

Well-being will be measured with VAS 3 hours post surgery and on postoperative day 1, 2 and 3.

Nausea will be measured with VRS 3 hours post surgery and on postoperative day 1, 2 and 3.

Total number of times the participant have been vomiting 3 hours post surgery and on postoperative day 1, 2 and 3.

All participants will be given oral Paracetamol 1g four times a day and Ibuprofen 400 mg three times a day for the first 72 postoperative hours. Any need for additional analgesics besides this will be registered. Consumption of antiemetics will be registered.

Any postoperative complications will be registered during the participants admission and on follow-up 28 days (+/- 2 days) and 12 months (+/- 14 days) after surgery

Participants will be requested to score their satisfaction with the cosmetic result on a scale from 0 (no scarring) to 10 (severe scarring)28 days (+/- 2 days) and 12 months (+/- 14 days) after surgery.

Participants are requested to fill in the questionnaire Female Sexual Function Index (FSFI) on sexual function and dyspareunia 28 days (+/- 2 days) and 12 months (+/- 14 days) after surgery.

The time from admission to discharge from the hospital is recorded.

Details about the technical aspects of performing TV NOTES cholecystectomy is recorded during and immediate after surgery.

Early overall postoperative pain measured with VAS, 3 hours after the operation as well as on the first postoperative day. Pain score will be assessed at rest and during mobilization from supine to erect posture.

Late postoperative pain measured with VRS on the second and third postoperative day. Pain score will be assessed at rest and during mobilization from supine to erect posture.

Pain localization (abdominal wall, intra-abdominal or shoulder pain) will be measured with VRS, 3 hours postoperatively as well as on the first postoperative day.

Pain localization (abdominal wall, intra-abdominal or shoulder pain) will be measured with VRS, on the second and third postoperative day.

gallstones/unwohlsein und ermüdung

Analgesic Effect of TAP Block After Laparoscopic Cholecystectomy

Treatment of Iron Overload With Deferasirox (Exjade) in Hereditary Hemochromatosis and Myelodysplastic Syndrome

The Effect of Transvaginal vs. Conventional Laparoscopic Cholecystectomy on the Postoperative Course

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