The patients were assigned to the complicated acute appendicitis group (Group C) based on the preoperative imaging findings (periappendiceal abscess formation or significant periappendiceal fat tissue contamination in ultrasonography and computed tomography), intraoperative exploration findings (presence of gangrenous appendicitis, perforation or abscess formation), and pathological examination findings (acute phlegmonous appendicitis, acute gangrenous appendicitis or acute perforated appendicitis).

The patients were assigned to the uncomplicated acute appendicitis group (Group UC) based on the increased diameter and wall thickness of the appendix and detection of minimal contamination in the surrounding fat tissue in the imaging tests; the presence of edema and the absence of gangrene, perforation or abscess in the the exploratory surgery of appendix, and confirmation of the diagnosis of acute appendicitis by the pathological examination findings

Acute Appendicitis

Appendectomy

Kahramanmaraş Sütçü İmam University

Preoperative Immature Granulocyte Count and Percentage for Acute Appendisitis

Preoperative Immature Granulocyte Count and Percentage for Complicated and Uncomplicated Appendisitis

Preoperative IG count of the patients to differentiate complicated and uncomplciated acute appendicitis

Preoperative IG count of the patients to select medically treatment patients of noncomplicated acute appendicitis

Preoperative IG percentage of the patients to differentiate complicated and uncomplciated acute appendicitis

Preoperative IG percentage of the patients to select medically treatment patients of noncomplicated acute appendicitis

Mehmet Buğra Bozan

Professor, Assistant

Kahramanmaras Sutcu Imam University

Sequential compression devices (SCDs) are applied during surgery.

No sequential compression devices are applied.

Blood Coagulation Disorder

Application of sequential compression devices in surgery.

Sequential compression devices (SCDs)

No sequential compression.

Swanson Center

Sequential Compression Devices Effect on Fibrinolysis in Plastic Surgery Outpatients

The Effect of Intraoperative Sequential Compression Devices on Fibrinolysis in Plastic Surgery Outpatients: A Randomized Trial

Prospective, randomized, controlled study.

Two sequences of ten healthy volunteers each will be performed :
During the first sequence, a biopsy of the gluteal area and another of the surrounding nail area of a finger will be sampled.Then, the cutaneous blood flux of the hand will be recorded at rest and during cooling and warming periods.
During the second sequence, two other biopsies of the surrounding nail area of two other fingers will be sampled.

Two sequences of ten primary Raynaud's syndrome each will be performed :
During the first sequence, a biopsy of the gluteal area and another of the surrounding nail area of a finger will be sampled.Then, the cutaneous blood flux of the hand will be recorded at rest and during cooling and warming periods.
During the second sequence, two other biopsies of the surrounding nail area of two other fingers will be sampled.

Two sequences of ten patients each will be performed :
During the first sequence, a biopsy of the gluteal area and another of the surrounding nail area of a finger will be sampled.Then, the cutaneous blood flux of the hand will be recorded at rest and during cooling and warming periods.
During the second sequence, two other biopsies of the surrounding nail area of two other fingers will be sampled.

Raynaud's Phenomenon Isolated Primary

Raynaud's Phenomenon (Secondary)

Healthy

Biopsy

CHU of Grenoble Alpes

Identification of TRP Channels as New Potential Therapeutic Targets in Primary and Secondary Raynaud's Phenomenon.

Identification of Transient Receptor Potential (TRP) Channels as New Potential Therapeutic Targets in Primary and Secondary Raynaud's Phenomenon.

Quantification of the expression of mRNA of TRP channels by RT PCR

RT PCR, laser speckle contrast imaging, infra red thermogrphy, tissue viability imaging

Immuno fluorescence with an anti-alpha smooth muscle cell antibody

University Hospital, Grenoble

Subjects will receive a new pair of diabetic shoes with BOA shoelace closure and a pair of AVEX Footbeat insoles, which include a micro-mobile compression pump. The entire system is named 'intervention shoes' for simplicity. They will be instructed to wear the intervention shoes on daily basis for 4 weeks for duration of at least 4 hours per day.

Subjects will receive a new pair of diabetic shoes with BOA shoelace closure and a pair of AVEX Footbeat insoles, which include a micro-mobile compression pump. The entire system is named 'intervention shoes' for simplicity. They will be instructed to wear the intervention shoes on daily basis for 4 weeks for duration of at least 4 hours per day.
Avex Footbeat: Subjects will receive diabetic shoes equipped with Boa Technology shoelace system and Footbeat compression insoles, which for simplicity will be named intervention shoes. All participants will be asked to wear the intervention shoes for duration of 4-weeks on daily basis (minimum 4 hours per day). Daily use of the intervention shoes will be assumed to improve balance, mobility, plantar sensation, lower extremity edema, and lower extremity skin perfusion.

Avex Footbeat

Sex: Female, Male

Ethnicity (NIH/OMB)

Race (NIH/OMB)

Region of Enrollment

Balance will be quantified by measuring body sway in medial-lateral direction using a validated wearable sensors technology (Balansens, Biosensics LLC) and body sway change after 4-weeks of daily use of AVEX Footbeat will be assessed compare to baseline. Th unit of measurement is cm.

Change in Balance From Baseline to 4 Weeks

Skin perfusion was quantified using Skin Perfusion Pressure Test (SPP) at the lower extremities at baseline and at 4-week (end point). The measurement of SPP was done using a device called Sensilase PAD-IQ (VASAMED). The unit of measurement is mmHg.

Change in Skin Perfusion From Baseline to 4 Weeks

Edema will be measured by traditional circumference change of ankle. The unit of measurement is cm.

Change in Lower Extremity Edema From Baseline to 4 Weeks

The change in plantar sensation after 4-weeks use of AVEX Footbeat will be assessed using vibratory perception threshold (VPT) test. The unit of this measurement is volt.

Change in Plantar Sensation From Baseline to 4-week

The change in stride velocity was quantified by gait speed measured using a validated wearable sensor (LEGSys, Biosensics, LLC). The unit of measurement is meter per second (m/s)

Change in Stride Velocity From Baseline to 4-week

Overall Study

Prof.

Diabetes

Lower Extremity Edema

Neuropathy;Peripheral

Foot Ulcer, Diabetic

Lymphatic Diseases

Subjects will receive diabetic shoes equipped with Boa Technology shoelace system and Footbeat compression insoles, which for simplicity will be named intervention shoes. All participants will be asked to wear the intervention shoes for duration of 4-weeks on daily basis (minimum 4 hours per day). Daily use of the intervention shoes will be assumed to improve balance, mobility, plantar sensation, lower extremity edema, and lower extremity skin perfusion.

Baylor College of Medicine

Micro-mobile Foot Compression and Diabetic Foot

Micro-mobile Foot Compression Device to Improve Motor-function in People With Diabetes and Loss of Protective Sensation

Only de-identified data and associated results will be published in peer-review papers or scientific abstracts. The de-identified data from changes in primary and secondary outcomes (e.g. changes in balance, gait, physical activity, edema, etc) may be shared upon approval of the sponsor.

Bijan Najafi, PhD

Professor of Surgery

Avex LLC

Eligible subjects will try a new offloading boot for 4 weeks

Diabetic Foot Ulcer

Offloading

A new offloading boot, which may enhance balance, gait, and lower extremity blood flow

Offloading boot : PulseFlow

Novel Offloading for Diabetic Foot Ulcers With PulseFlow: A Prospective Study

skin perfusion measured in the ankle using Sensilase device

the quality of walking while wearing Pulseflow offflaoding compared to standard offloading

body sway measured while wearing Pulseflow offflaoding compared to standard offloading

assessing spontaneous daily physical activities using a special non-invasive sensor with accelerometers

adherence to wear offloading boot by downloading from the study device to a specific developed software.

Measuring Pain with VA Pain Questionnaire

Only de-identified data and associated results will be published in peer-reviewed papers or scientific abstracts

gangrene/ödem

Preoperative Immature Granulocyte Count and Percentage for Acute Appendisitis

Sequential Compression Devices Effect on Fibrinolysis in Plastic Surgery Outpatients

Identification of TRP Channels as New Potential Therapeutic Targets in Primary and Secondary Raynaud's Phenomenon.

Micro-mobile Foot Compression and Diabetic Foot

Novel Offloading for Diabetic Foot Ulcers With PulseFlow: A Prospective Study

Die vollständigste Datenbank für Heilkräuter, die von der Wissenschaft unterstützt wird