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A 49 year old female patient with anorexia nervosa was admitted to the hospital because of treatment-refractory hyperuricemia and gout. Medical history and clinical findings were compatible with primary gout and uric acid nephropathy. The patient stated that she regularly took allopurinol. In the
BACKGROUND
This is an update of a Cochrane review first published in 2006. Gout is one of the most common rheumatic diseases worldwide. Despite the use of colchicine as one of the first-line therapies for the treatment of acute gout, evidence for its benefits and harms is relatively
(1) Febuxostat is a selective inhibitor of xanthine oxidase. Its use in the management of hyperuricemia and gout is being studied. (2) In a 52-week, phase III randomized clinical trial, febuxostat was superior to allopurinol for lowering uric acid levels. Its efficacy in preventing gout attacks was
A 41-year-old male was referred for autopsy from a hospital with a diagnosis of sepsis of uncertain etiology. As he had recently been attached to a military base in Southeast Asia, and had only just returned home, there was considerable concern that an unknown infectious agent may have been
OBJECTIVE
To evaluate the efficacy and safety of oral prednisolone in the treatment of acute gout compared with non-steroidal anti-inflammatory drugs (NSAIDs).
METHODS
A comprehensive search of databases in both Chinese and English was performed. Data from the selected studies were extracted and
OBJECTIVE
Nonsteroidal antiinflammatory drugs (NSAID) are used as first-line agents to treat acute gout. Recent trials suggest a possible first-line role for corticosteroids.
METHODS
We conducted a metaanalysis of randomized controlled trials (RCT) evaluating corticosteroid versus NSAID therapy
In patients with a history of gout, there could be a delay in diagnosis of a septic joint, which increases morbidity and mortality. The literature reports rare instances of coexistent gout and septic arthritis. We present a 64-year-old male with non-ischemic cardiomyopathy, supported by a HeartWare
Although gout and hyperuricaemia are usually thought of as conditions of indulgent male middle age, in addition to the well-known uricosuria of the newborn, there is much of importance for the paediatric nephrologist in this field. Children and infants may present chronically with stones or acutely
OBJECTIVE
Despite widespread use of colchicine, the evidence basis for oral colchicine therapy and dosing in acute gout remains limited. The aim of this trial was to compare low-dose colchicine (abbreviated at 1 hour) and high-dose colchicine (prolonged over 6 hours) with placebo in gout flare,
BACKGROUND
Gout is one of the most common rheumatic diseases worldwide. Colchicine is regarded as beneficial in the treatment of acute gout, but has a high frequency of gastrointestinal adverse events.
OBJECTIVE
To evaluate the efficacy and safety of colchicine for relief of the signs and symptoms
To investigate the usefulness of allopurinol for the treatment of hyperuricemia in birds, experimental studies were performed using the physiologically occurring post-prandial hyperuricaemia in birds of prey as a model. Pre-and post-prandial plasma concentrations of allopurinol, oxypurinol,
BACKGROUND
Pacific people suffer disproportionately poorer health and reduced life expectancy at birth compared to the total New Zealand population.
OBJECTIVE
To assess causes of excess morbidity in the Pacific population, and identify lesser known or previously unknown causes which require further
Medulla oblongata myelinolysis is an extremely rare manifestation of extrapontine myelinolysis (EPM). Herein, we report a case of a 34-year-old man with a history of gout who presented repeated vomiting and diarrhea after ingesting 15 colchicine pills. A hyponatremia diagnosis was given and after an