7 Ergebnisse
Histoplasma capsulatum is the causative agent of human histoplasmosis, which can cause respiratory and systemic mycosis in immune-compromised individuals. Lysine acetylation, a protein posttranslational protein modification, is widespread in both eukaryotes and prokaryotes. Although increasing
BACKGROUND
Preclinical and epidemiologic studies suggest that garlic intake is inversely associated with the progression of cancer and cardiovascular disease.
OBJECTIVE
We designed a study to probe the mechanisms of garlic action in humans.
METHODS
We conducted a randomized crossover feeding trial
Miliary shadows on chest imaging have wide differential diagnoses. The most common etiology is infectious, such as miliary tuberculosis (TB) and histoplasmosis, but miliary shadows can be the presentation of sarcoidosis, pneumoconiosis, and secondary metastasis to the lungs from primary cancers of
OBJECTIVE
To determine the activity of newer triazoles against strains of Histoplasma capsulatum resistant to fluconazole.
METHODS
Susceptibility testing was performed on 17 paired pre- and post-treatment H. capsulatum isolates from patients with AIDS who failed fluconazole.
RESULTS
The median MICs
BACKGROUND
Lignin fractions of Lentinus edodes mycelia extract (LEM) have shown anti-HIV and immunopotentiating activity. However, the action point of lignin-carbohydrate complex has not been elucidated. In order to elucidate their action point, DNA microarray analysis was performed, using mouse
Myeloid differentiation primary response gene 88 (MYD88), which activates the nuclear factor kappa B (NF-κB) pathway, is important for the growth of lymphoma and leukaemia cells. In this study, we investigated the effects of ST2825, a synthetic peptidomimetic compound which inhibits MYD88
One of the most significant challenges of inflammatory bowel disease (IBD) research is to understand how alterations in the symbiotic relationship between the genetic composition of the host and the intestinal microbiota, under impact of specific environmental factors, lead to chronic intestinal