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methyl salicylate/hochempfindlichkeit
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13 Ergebnisse
Potential dangers from topical preparations containing methyl salicylate.
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Methyl salicylate (oil of wintergreen) is widely available in many over-the-counter liniments, ointments, lotions or medicated oils for the relief of musculoskeletal aches and pains. Ingestion of methyl salicylate poses the threat of severe, rapid-onset salicylate poisoning because of its liquid,
Vicia faba Hypersensitivity and ASA Intolerance in a Farmer: A Case Report.
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The IgE-mediated allergic reactions to food are caused, generally, by ingestion. However, they can be rarely induced by exposure to airborne food particles through the handling or the cooking. Vicia faba is a vegetable which belongs to Legumes or Fabaceae family, Fabales order. Allergic reactions
Review of allergic and photoallergic contact dermatitis from an ingredient in a medicament vehicle consisting of a compress, poultice, plaster, and tape.
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The topical application of a medicament vehicle consisting of a compress, poultice, plaster, and tape containing a nonsteroidal anti-inflammatory drug or methyl salicylate is prevalent in Japan. The method is effective for conveying ingredients to the muscles via the skin for the relief of muscular
Chitosan-based films containing nanoemulsions of methyl salicylate: Formulation development, physical-chemical and in vitro drug release characterization
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Transdermal patches for analgesic purposes are widely used, however, their occlusive characteristics can often cause allergic reactions, irritating contact dermatitis, and allergic contact dermatitis upon extended use. Chitosan is a natural positively charged bioadhesive polysaccharide with several
Optimization of the THP-1 activation assay to detect pharmaceuticals with potential to cause immune mediated drug reactions.
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Despite important impacts of systemic hypersensitivity induced by pharmaceuticals, for such endpoint no reliable preclinical approaches are available. We previously established an in vitro test to identify contact and respiratory allergens based on interleukin-8 (IL-8) production in THP-1 cells.
Airway morphology and function of rats following dermal sensitization and respiratory challenge with low molecular weight chemicals.
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Local lymph node activation and increased total serum IgE levels are suggested to be predictive parameters of airway hypersensitivity caused by low molecular weight (LMW) chemicals. Whether increases of total serum IgE are indicative of actual induction of specific airway reactions (morphological
Assessment of the skin sensitization potential of topical medicaments using the local lymph node assay: an interlaboratory evaluation.
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The murine local lymph node assay (LLNA) is a method for the predictive identification of chemicals that have a potential to cause skin sensitization. Activity is measured as a function of lymph node cell (LNC) proliferative responses stimulated by topical application of test chemicals. Those
[Standard epicutaneous tests: interpretation of the statistical findings of the last five years].
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The statistical evaluation of the epicutaneous tests performed between 1976-1980 in the Department of Dermatology at the University Hospital in Hamburg revealed 1320 positive reactions to different contact allergens in 5348 patients (25%). The most frequent responses were found with nickel sulfate.
Gene expression profiles in auricle skin as a possible additional endpoint for determination of sensitizers: A multi-endpoint evaluation of the local lymph node assay.
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The murine local lymph node assay (LLNA) is widely used to test chemicals to induce skin sensitization. Exposure of mouse auricle skin to a sensitizer results in proliferation of local lymph node T cells, which has been measured by in vivo incorporation of H3-methyl thymidine or
Evaluation of an ex vivo murine local lymph node assay: multiple endpoint comparison.
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The local lymph node assay (LLNA) is used to assess the skin sensitization potential of chemicals. In the standard assay, mice are treated topically on the dorsum of both ears with test substance for 3 days. Following 2 days of rest, the initiation of the hypersensitivity response is evaluated by
Local lymph node activation and IgE responses in brown Norway and Wistar rats after dermal application of sensitizing and non-sensitizing chemicals.
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The local lymph node assay (LLNA) and the IgE test in the mouse are proposed models for predictive recognition of low molecular weight chemicals causing IgE-mediated allergic airway reactions in man. Since rats are commonly used in routine toxicity studies and a previous study (Arts et al. (1996)
Phospholipidomic Profile Variation on THP-1 Cells Exposed to Skin or Respiratory Sensitizers and Respiratory Irritant.
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Occupational exposure to low molecular weight reactive chemicals often leads to development of allergic reactions such as allergic contact dermatitis and respiratory allergies. Further insights into the interaction of these chemicals with physiopathological relevant cellular models might provide the
Topical acne drugs: review of clinical properties, systemic exposure, and safety.
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This review examines the commonly available topical acne agents and factors that determine their percutaneous absorption. Reported and theoretical adverse effects from systemic exposure are detailed. The topical retinoid class, which includes tretinoin, adapalene and tazarotene, and the topical
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