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15 Ergebnisse

Safety, Tolerability, PK/PD of FE 203799 in Adults With Lymphomas

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OUTLINE: Multi-center, double-blind, placebo-controlled, ascending dose, randomized Phase IB/2A study to assess the safety, tolerability, pharmacokinetic (PK) and pharmacodynamic (PD) profile of s.c. FE 203799 in patients diagnosed with Hodgkin's lymphoma (HL) or non-Hodgkin's lymphoma (NHL)

Misoprostol Versus Effox as Cervical Ripening Agent Prior Surgical Evacuation

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Objective: To compare the efficacy of the individual use of Misoprostol or Effox or their combination as cervical ripening agents in cases with 1st trimesteric pregnancy loss candidate for surgical evacuation. Study Design: A randomized Single-blind comparative study. Setting: The Obstetrics and

Efficacy of Chloroquine (CQ) Alone Compared to Concomitant CQ and Primaquine for Plasmodium Vivax Infection

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1. OBJECTIVE- To assess the efficacy of co-administered chloroquine+primaquine (CQ+PQ) vs.CQ alone (PQ being postponed up to day 28 of CQ therapy) as a schizontocidal therapy (28-day follow-up) and as radical cure among uncomplicated P. vivax malaria (6-month follow-up). Specifically: - To measure

Trial Evaluating Chemoprophylaxis Against Travelers' Diarrhea - Prevent TD

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The primary efficacy outcome will be assessed by review of the symptom memory aid (TravMil diary). Subjects will follow a symptom memory aid from the onset of a disease episode and record relevant symptomatology (date/time and number of diarrheal episodes, associated symptoms such as fever,

Effect of Adjunctive Misoprostol Treatment on Blood Loss at Vaginal Delivery

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Background Some maternal blood loss normally occurs at the time of vaginal delivery. The best estimates indicate that a loss of approximately 500 mL is average, with a range of about 250-700 mL.[1,2] Some of this bleeding arises from birth canal lacerations or surgical incisions (i.e., episiotomy),

To Determine the Effect of Honey Enema in the Treatment of Patients With Acute Pouchitis

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Pouchitis is the most common long-term complication of ileal pouch-anal anastomosis (IPAA) in ulcerative colitis (UC). Pouchitis is defined as a clinical syndrome of watery, frequent, at times bloody stool accompanied by urgency, incontinence, abdominal cramps, malaise, and fever. The PDAI

Oral Misoprostol for Cervical Priming Before Hysteroscopy

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All patients admitted for hysteroscopy were offered participation in the study, and those choosing to participate were assessed according to the inclusion and exclusion criteria of the study protocol. The investigators included all non pregnant patients who were considered medically fit and

A Trial to Study the Effect of Long Term Vitamin D Supplementation on Insulin Sensitivity

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Volunteers will be recruited from amongst the preventive health check subjects, neighboring offices, hospital employees and corporate associates of SBISR after obtaining a detailed informed consent. The study will include 300 subjects with the following selection criteria. INCLUSION CRITERIA 1. 35

Dasatinib Combination for Chronic Lymphocytic Leukemia(CLL) With Refractory Disease

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Chronic lymphocytic leukemia (CLL) is the most common leukemia in the western world. The disease mostly affects the elderly. At present no curative therapy is available. Although the majority of patients initially do respond to chemotherapy, most patients eventually develop drug resistance. The

Perioperative Pain Control With Celecoxib (Celebrex) in Total Knee Arthroplasty

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Total knee replacement is an effective method to treat end-stage osteoarthritis. However, post-operative pain is still a bothering problem. Pre-emptive analgesia is defined as an antinociceptive treatment which prevents pain before its onset. Preoperative analgesia is thought more effective than an

Study of 3,5-Diiodothyropropionic Acid (DITPA) in Hypercholesterolemic Patients

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INTRODUCTION BACKGROUND: In recent years, the need to achieve increasingly ambitious therapeutic goals for dyslipidemias has prompted the search for more potent pharmacological agents to lower circulating atherogenic lipoprotein concentrations and enhance reverse cholesterol transport (RCT). While

Long-Term Lamivudine Therapy for Chronic Hepatitis B

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The major aims of this study are to evaluate the long-term efficacy and safety of lamivudine therapy and the possibility of stopping therapy in a cohort of patients with chronic hepatitis B who have a maintained response to treatment. Lamivudine is a nucleoside analogue with potent activity against

Treatment of Chronic Cryptosporidiosis in AIDS Patients

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Cryptosporidium parvum, an intracellular protozoan parasite, is a frequent cause of chronic diarrhea in HIV-infected patients, causing significant morbidity and mortality. Highly effective antiparasitic treatment for this infection is not currently available. Paromomycin and azithromycin have some
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