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myocardial infarction/l scopolamin

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Effects of low dose transdermal scopolamine on heart rate variability in acute myocardial infarction.

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OBJECTIVE We hypothesized that by enhancing parasympathetic activity, low dose transdermal scopolamine would increase heart rate variability after myocardial infarction. BACKGROUND Low heart rate variability is associated with increased mortality after acute myocardial

Scopolamine increases vagal tone and vagal reflexes in patients after myocardial infarction.

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OBJECTIVE The goal of this study was to assess the hypothesis that transdermal scopolamine would increase vagal activity in patients after myocardial infarction. BACKGROUND In postmyocardial infarction patients, low heart rate variability and reduced baroreceptor reflex sensitivity are associated

Influence of transdermal scopolamine on cardiac sympathovagal interaction after acute myocardial infarction.

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In 41 survivors of acute myocardial infarction (AMI) a prospective study was performed in 2 sequential phases. In phase 1, the role of baroreflex sensitivity and heart rate variability as predictors of inducible and spontaneous sustained ventricular tachyarrhythmias was evaluated. In phase 2, the

Low dose transdermal scopolamine increases cardiac vagal tone in patients after acute myocardial infarction.

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OBJECTIVE To investigate whether transdermal scopolamine increased cardiac vagal activity in patients during the acute phase of myocardial infarction. METHODS 30 patients with a first acute myocardial infarction and preserved sinus rhythm who were on no drug that could influence the sinus node were

Low doses of scopolamine increase cardiac vagal tone in the acute phase of myocardial infarction.

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BACKGROUND Reduced cardiac vagal tone in patients with myocardial infarction (MI) is associated with a high risk of sudden death. Muscarinic blocking agents in small doses induce a paradoxical increase in cardiac vagal activity in normal subjects. We tested whether low doses of scopolamine delivered

[Effects of scopolamine plus atropine on experimental myocardial infarction in rabbits].

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Experimental and clinical evidence documents the beneficial effects of blocking sympathetic activity and modulating heart rate to reduce risk for lethal events in ischemic heart disease. Beside beta-adrenergic receptor blockade, vagal activation is a meaningful approach but not yet easily

Scopolamine improves autonomic balance in advanced congestive heart failure.

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BACKGROUND Sympathetic hyperactivity and parasympathetic withdrawal in patients with congestive heart failure correlate closely with disease severity and overall survival. The modulating effects of drugs on the autonomic dysfunction may contribute to improve survival. Low-dose scopolamine has a

Do increases in markers of vagal activity imply protection from sudden death? The case of scopolamine.

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BACKGROUND Low-dose scopolamine increases heart rate variability (HRV) in patients with a prior myocardial infarction (MI). This observation, combined with the evidence that elevated cardiac vagal activity during acute myocardial ischemia is antifibrillatory, has generated the hypothesis that

Effects of transdermal scopolamine on heart rate variability in normal subjects.

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A decrease in cardiac parasympathetic tone is a recognized finding in patients with ischemic heart disease, sudden cardiac death and heart failure, correlating closely with disease severity and overall survival. To study the clinical potential of vagomimetic intervention, the effect of transdermal
OBJECTIVE Our aims were 1) to assess whether oral pirenzepine could increase indexes of cardiac vagal activity in postinfarction patients, and 2) to compare the effects of this agent with those of transdermal scopolamine. BACKGROUND Depression of vagal tone and reflexes predicts a poor arrhythmic
A forensic method comprising solid phase extraction and HPLC analysis was developed for the detection and confirmation of atropine and scopolamine, the main toxic alkaloids of Datura stramonium and Datura ferox. This method allowed the direct coupling of an electrospray (ZMD) mass selective detector
This study was performed to compare the incidence of prebypass myocardial ischemia in patients receiving fentanyl and enflurane for anesthesia along with either pancuronium or vecuronium. Ninety-eight patients with normal left ventricular function were randomly allocated to receive either

Autonomic control of heart rate: pharmacological and nonpharmacological modulation.

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The evidence of the predictive value of autonomic markers has generated a growing interest for interventions able to influence autonomic control of heart rate. The hypothesis is that an increase in cardiac vagal activity as detected by an increase in heart rate variability (HRV) or baroreflex
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