Rickettsiae Infections

An in-house rickettsial IgG ELISA test will be used for this study to determine previous rickettsial infections by measuring IgG levels. All specimens will be tested for IgG antibodies using ELISA tests for scrub typhus (Orientia tsutsugamushi strains Karp, Kato, Gilliam and TA716), murine typhus (Rickettsia typhi strain type Wilmington), and spotted fever rickettsiosis (Rickettsia honei and Rickettsia conorii). If the sample tests positive, it will be retested for the same antigens using the IFA test. The sample will be considered positive if both the ELISA and the IFA are positive.

MORU in-house ELISA test followed by IFA if positive

Myanmar Oxford Clinical Research Unit

Rickettsiae in Myanmar

Background Seroprevalence of Rickettsial Infections in Myanmar

Proportion of patients with a positive IgG ELISA, subsequently confirmed with IFA, for scrub typhus (Orientia tsutsugamushi strains Karp, Kato, Gilliam and TA716), murine typhus (Rickettsia typhi strain type Wilmington), and spotted fever rickettsiosis (Rickettsia honei and Ricketsia conorii).

Correlation of different patient characteristics with a positive ELISA and IFA test indicating a previous rickettsial infection.

National Health Laboratory, Myanmar

Magway General Hospital, Magway

Monywa Hospital, Sagaing

Mandalay General Hospital and University of Medicine, Mandalay

University of Medicine, Magway

Mahidol Oxford Tropical Medicine Research Unit

Medical Action Myanmar

child with fever and a negative malaria RDT

apparently healthy child with a negative RDT

Malaria

Centre de Santé de Commune

Can Treatment of Malaria be Restricted to Parasitologically Confirmed Malaria?

Can Treatment of Malaria be Restricted to Parasitologically Confirmed Malaria? A School-Based Prospective, Exposed/Non Exposed to Fever, Study in Benin.

Jean-François Faucher, MD

Institut de Recherche pour le Developpement

Institut de Médecine et d'Epidémiologie Appliquée - Fondation Internationale Léon M'Ba

Field microscopy is the main method of malaria diagnosis

Paracheck Pf® device (Rapid Diagnostic Test) is the main method for malaria diagnosis

Fever

Malaria diagnosis based on microscopy and or Paracheck Pf®. Artemether/Lumefantrine (20mg/120mg) is first-line drug in all arms

ophrys fusca/fieber

Rickettsiae in Myanmar

Can Treatment of Malaria be Restricted to Parasitologically Confirmed Malaria?

Parasite-based Diagnosis for Malaria in Uganda: Feasibility and Cost-Effectiveness

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