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pediatric obesity/brustkrebs
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Adolescent obesity and adult male breast cancer in a cohort of 1,382,093 men.
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Male breast cancer (MBC) accounts for 1% of all breast cancer. Adult obesity and tallness are risk factors for MBC, but the role of adolescent fatness is largely unknown. We aimed to assess the association between body mass index (BMI) in adolescence and the incidence of MBC in a large cohort of 16-
Body size at different periods of life and breast cancer risk.
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The inconclusive findings of past analytic epidemiologic studies on diet and breast cancer may have resulted from the inability of these studies to assess early dietary exposures. The role of macronutrient intake during early life can be indirectly studied, however, by examining past and present
Adolescent obesity and midlife cancer risk: a population-based cohort study of 2·3 million adolescents in Israel.
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Measured adolescent body mass index and adult breast cancer in a cohort of 951,480 women.
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Body mass index (BMI) in adolescence, studied predominantly as a self-reported risk factor for breast cancer (BC), may have been subjected to recall bias. We examined the association between measured BMI in adolescence and the incidence of BC by menopausal status. 951,480 Jewish Israeli females aged
Childhood obesity and the timing of puberty.
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The potential relationship between childhood obesity and earlier puberty onset has major public health implications. Earlier menarche in girls is associated with increased risk of adult obesity, type 2 diabetes and breast cancer. Current methods for assessing puberty are unreliable, with a lack of
BRCA1 and acetyl-CoA carboxylase: the metabolic syndrome of breast cancer.
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Breast cancer-associated mutations affecting the highly-conserved C-terminal BRCT domains of the tumor suppressor gene breast cancer susceptibility gene 1 (BRCA1) fully disrupt the ability of BRCA1 to interact with acetyl coenzyme A carboxylase alpha (ACCA), the rate-limiting enzyme catalyzing de
Childhood obesity as a predictor of morbidity in adulthood: a systematic review and meta-analysis.
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Obese children are at higher risk of being obese as adults, and adult obesity is associated with an increased risk of morbidity. This systematic review and meta-analysis investigates the ability of childhood body mass index (BMI) to predict obesity-related morbidities in adulthood. Thirty-seven
Childhood obesity: increased risk for cardiometabolic disease and cancer in adulthood.
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Prevalence of childhood obesity has worldwide more than doubled since 1980. Underlying factors are complex and are far from completely understood. Strategies to prevent childhood obesity have mainly focused on behavioral intervention; and obesity therapy was mainly based on lifestyle modification to
USPSTF recommendations you may have missed amid the breast cancer controversy.
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The USPSTF recommends aspirin for the prevention of stroke and heart attack for those at risk, and screening for major depression and childhood obesity.
Adolescent obesity and puberty: the "perfect storm".
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Obesity is the most serious long-term health risk currently facing America's adolescents. Weight gain during adolescence carries a higher risk for adult obesity and the metabolic syndrome. This review highlights early adolescence as a particularly high-risk time for weight gain due to the synergy of
Birthweight, childhood overweight, height and growth and adult cancer risks: a review of studies using the Copenhagen School Health Records Register.
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Occurrence and timing of childhood overweight and mortality: findings from the Third Harvard Growth Study.
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OBJECTIVE
To assess the mortality experience of participants in the Third Harvard Growth Study (1922-1935) who provided ≥ 8 years of growth data.
METHODS
A total of 1877 participants provided an average of 10.5 body mass index measurements between age 6 and 18 years. Based on these measurements, the
Early menarche and its consequence in Korean female: reducing fructose intake could be one solution.
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The mean age at menarche (AAM) of Korean females has been rapidly decreasing over the last 50 years; currently, the prevalence of early menarche (<12 years) is 22.3%. Female adolescents who experience early menarche are known to be at greater risk of psychosocial and behavioral problems along
CYP19A1 promoter methylation in saliva associated with milestones of pubertal timing in urban girls.
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BACKGROUND
Childhood obesity and early puberty are intermediate risk factors for later metabolic and reproductive disorders including diabetes, polycystic ovarian syndrome (PCOS), and breast cancer. Atypical methylation patterns in genes related to hormone and adipose metabolism, such as CYP19A1
Pathophysiology of polycystic ovarian disease: new insights.
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The incidence of polycystic ovarian disease (PCOD) varies from 0.6 to 92%, depending on the parameters analysed, PCOD has been reported to appear in association with Cushing's Syndrome, adrenal hyperplasia, hypothyroidism, adrenal and ovarian tumours and some genetic abnormalities. The controversy
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