CPAP always deliver air with the same pressure

Auto-CPAP changes the pressure delivered depending on events detected at any time (apnea, hypopnea …) and applies the lowest pressure required to eliminate events.

Sleep Apnea Syndromes

CPAP is a device that applies continous fixed positive pressure to the airways in order to keep them opened during sleep

Fixed CPAP

Auto-adjusting CPAP is a device that applies auto-adjusting continous positive pressure to the airways in order to keep them opened during sleep

Auto-adjusting CPAP

CHU Grenoble Alpes

Decrease Obstructive Sleep Apnea (OSA) Sympathetic Tone : Impact of APAP vs CPAP

Decrease in Sympathetic Tone in OSA Patients: Is CPAP More Effective Than APAP ?

Change from Baseline Sympathetic tone at 1 months

Change from Baseline in 24 hours ambulatory systolic blood pressure

Clinical BP on 3 occasions, SBP and BP will be assessed. Mean BP calculated as DBP+1/3(SBP-DBP)

24h urine samples will be collected and acidified with acetic acid, stored at -20°C until analysis. Catecholamines (epinephrine, norepinephrine, and dopamine) will be measured in one milliliter of urine by high-performance liquid chromatography with electrochemical detection (Coularray Detector, ESA Dionex, Chelmsford, USA).

We will use these mathematical methods to analyze a signal over time: temporal analysis, Fourier transformation and wavelet transformation.
High-frequency (HF) translates fluctuations in parasympathetic activity to cardiac destination, modulated by ventilatory characteristics (frequency, courant volume).

We will use these mathematical methods to analyze a signal over time: temporal analysis, Fourier transformation and wavelet transformation.
Low frequency (LF) is classically considered to reflect the activity of the sympathetic system rather than the parasympathetic system.

University Hospital, Grenoble

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior.

ResMed

Agir pour les maladies chroniques

Pre-Hypertension

RMT consists of six bouts of 5-min of volitional hyperpnoea . After each RMT bout, participants will breathe room air for 5 minutes.

RMT and IH consist of six bouts of 5-min of volitional hyperpnoea. After each RMT bout, participants will breathe a hypoxic gas mixture (10.5% O2 ) for 5 minutes.

RMT + IH

Control

Exercise Physiology Lab, Institute of Human Movement Sciences and Sport, ETH Zurich

Respiratory Muscle Training and Intermittent Hypoxia: Additive Health Effects?

Acute Effects of Intermittent Respiratory Muscle Training and Hypoxia on Cardiovascular and Sleep Parameters in Elderly Persons With Prehypertension

Blood pressure before, during, and after each intervention measured with an automated sphygmomanometer

Carotid-femoral pulse wave velocity before and after each intervention, assessed with a device that simultaneously records (non-invasively) pressure signals from the carotid and femoral arteries

Cardiac output before, during, and after each intervention measured with impedance cardiography

Total peripheral resistance before, during, and after each intervention measured with impedance cardiography

Baroreflex sensitivity before and after each intervention assessed with photo plethysmography

Heart rate variability measured before, during and after each intervention with impedance cardiography

Peripheral oxygenation during sleep measured at home after each intervention with a finger pulse oxymeter

Sleep efficiency measured at home after each intervention with an actigraph

Sleep quality (i.e. "How well did you sleep?" and "How recovered are you?") measured at home after each intervention with a visual analog scale (VAS). The two VAS consists each of a 10cm-horizontal line, with the left end of the lines representing low sleep quality ("slept very badly" and "not recovered at all", respectively) and the right end representing good sleep quality ("slept very well" and "completely recovered", respectively). Participants are asked to draw a vertical line in between the two ends on each of the two VAS.

Swiss Federal Institute of Technology

No intervention, observational comparison group

Sleep hygiene information and local sleep resources

Obese

Pregnancy

Sleep Disordered Breathing

CPAP is a device that has a mask worn over the nose that is attached to a device that provides positive airway pressure. CPAP is worn while sleeping, it splints open the airway and prevents apneas (cessation of breathing) and hypopneas (reduced airflow while breathing).

CPAP

sham-CPAP

Information about sleep apnea and healthy sleep. Information about local sleep resources

Sleep hygiene

Magee-Womens Hospital of the UPMC

Sleep Disordered Breathing, Obesity and Pregnancy Study (SOAP)

Preeclampsia, Gestational diabetes, Gestational age at delivery, Indication for delivery, Birthweight, Cord gases

prehypertension/hypoxie

Decrease Obstructive Sleep Apnea (OSA) Sympathetic Tone : Impact of APAP vs CPAP

Respiratory Muscle Training and Intermittent Hypoxia: Additive Health Effects?

Sleep Disordered Breathing, Obesity and Pregnancy Study (SOAP)

Pituitary Derived-Intermedin is an Estrogen-Modulated Factor for Reducing Blood Pressure

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