A 15 kDa selenium-containing protein ("selenoprotein") is disclosed. The protein is shown to be differentially expressed in cancer cells, such as prostate cancer cells. There is a correlation between the presence of a polymorphism at nucleotide positions 811 and 1125 of the 15 kDa selenoprotein gene, and the presence of cancer. This polymorphism is more prevalent in the African American population. The determination of an individual's genotype may be used as an indicator of the need for dietary selenium supplementation to inhibit tumor development. Compositions including the isolated protein, specific binding agents that recognize the protein, as well as underlying nucleic acid sequences are presented, as are methods of using such compositions.

The United States of America as represented by the Department of Health and Human Services

The Board of Trustees of the University of Illinois

Mammalian selenoprotein differentially expressed in tumor cells

The present disclosure provides a method for the identification of nucleotide sequences which encode selenoproteins. Nucleotide sequences are translated in all potential reading frames, those with a relatively large number of UGA or TGA codons are noted, and frameshift-dependent open reading frames and SECIS elements are identified as associated with selenoprotein coding sequences, especially those within or overlapping known open reading frames. Further provided are selenoprotein coding sequences which are associated with certain viruses (e.g., HIV and Ebola), cancer-related genes and coding sequences related to normal functioning of the immune system.

selenoprotein/krebs

Mammalian selenoprotein differentially expressed in tumor cells

Mammalian selenoprotein differentially expressed in tumor cells

Mammalian selenoprotein differentially expressed in tumor cells

Selenoproteins, coding sequences and methods

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