A method for in-vivo detection of premalignant oral lesions and oral carcinomas includes the step of applying to oral tissue a non-toxic dye other than toluidine blue O, selected from compounds having structure ##STR1## and ionic derivatives thereof, wherein R.sup.1 is H, or lower alkyl group or N(R.sup.3)2, R.sup.2 is N, S or O, and R.sup.3 is H or a lower alkyl group.

Zila Pharmaceuticals, Inc.

Methods and compositions for in-vivo detection of oral cancers precancerous conditions

A novel method of detecting and diagnosing lung cancers by monitoring and analyzing expired lung air for the presence of selected aromatic amines, particularly aniline and ortho-toluidine, is provided.

Monell Chemical Senses Center

University of Pennsylvania

Method of detecting the presence of bronchogenic carcinoma by analysis of expired lung air

The present invention is directed to a novel multi-spectral contrast agent-enhanced polarized light imaging technique that enables rapid imaging of large tissue fields. The imaging device includes a tunable monochromatic light source and a CCD camera. Linear polarizers are placed into both the incident and collected light pathways in order to limit the measurement volume to the superficial tissue layers. To enhance the tumor contrast in the image, aqueous solutions of toluidine blue or methylene blue are topically applied.

toluidine/krebs

Methods and compositions for in-vivo detection of oral cancers precancerous conditions

Method of detecting the presence of bronchogenic carcinoma by analysis of expired lung air

Polarized light imaging devices and methods

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