Benefits of Eggs in Combination With a Plant-based Diet
Λέξεις-κλειδιά
Αφηρημένη
Περιγραφή
Results from studies involving cells, animal models and clinical trials have demonstrated that lutein and zeaxanthin potentially protect against chronic diseases, including age-related macular degeneration, cataracts, coronary heart disease and stroke. Plasma concentrations of lutein and zeaxanthin are closely associated with their antioxidant properties and with their protection against reactive oxygen species (ROS).
Choline is recognized as an essential nutrient for health because of its many functions in growth and development, as well as neurological function and formation of membrane phospholipids, including phosphatidylcholine (PC) and sphingomyelin.
Therefore the objective of this study is to demonstrate that inclusion of eggs in a plant-based diet will potentiate the benefits of this healthy diet by increasing plasma concentrations of lutein, zexanthin and choline presents in egg yolks and theoretically increase the antioxidant and anti-inflammatory actions of these components. This would be potentially more important in those individuals with metabolic syndrome, which is the target population of this intervention.
Ημερομηνίες
| Τελευταία επαλήθευση: | 05/31/2020 |
| Πρώτα υποβλήθηκε: | 01/12/2020 |
| Υποβλήθηκε εκτιμώμενη εγγραφή: | 01/14/2020 |
| Δημοσιεύτηκε για πρώτη φορά: | 01/20/2020 |
| Υποβλήθηκε τελευταία ενημέρωση: | 06/03/2020 |
| Δημοσιεύτηκε η τελευταία ενημέρωση: | 06/08/2020 |
| Ημερομηνία έναρξης της πραγματικής μελέτης: | 01/12/2020 |
| Εκτιμώμενη κύρια ημερομηνία ολοκλήρωσης: | 06/29/2021 |
| Εκτιμώμενη ημερομηνία ολοκλήρωσης μελέτης: | 12/30/2021 |
Κατάσταση ή ασθένεια
Παρέμβαση / θεραπεία
Other: Egg intake
Other: Egg Subsitute
Φάση
Ομάδες βραχιόνων
| Μπράτσο | Παρέμβαση / θεραπεία |
|---|---|
| Experimental: Egg intake Consumption of 2 eggs with spinach daily for breakfast for 4 weeks | Other: Egg intake Participants will be randomly allocated to consume either 2 eggs or 2 egg substitutes with spinach daily for 4 weeks and after a 3-week wash out, they will be allocated to the alternate treatment |
| Experimental: Egg Subsitute Consumption of 2 egg substitutes daily for breakfast for 4 weeks | Other: Egg Subsitute Egg Subsitute with spinach per day |
Κριτήρια καταλληλότητας
| Επιλέξιμες ηλικίες για μελέτη | 35 Years Προς την 35 Years |
| Φύλα επιλέξιμα για μελέτη | All |
| Δέχεται υγιείς εθελοντές | Ναί |
| Κριτήρια | Inclusion Criteria: - All genders - 35-70 years - Metabolic syndrome (based on 3 out of 5 characteristics: waist circumference. 88 cm for women and > 102 cm for men; plasma triglycerides > 150 mg/dL, blood pressure > 135/85 mm Hg, fasting glucose > 100 mg/dL and HDL < 40 mg/dL for men and < 50 mg/dL for women) - Willing to consume a spinach omelet made with 2 eggs or the equivalent amount of egg substitute daily for 4 weeks each - Willing to follow a plant-based diet for 13 weeks - Not have cardiovascular disease, high cholesterol, diabetes, cancer, liver or renal disease - Proficient in English Exclusion Criteria: - Self-reported diabetes, cardiovascular disease, history of stroke, liver disease or cancer - Taking glucose lowering medications - Triglycerides > 500 mg/dL - Cholesterol > 240 mg/dL - Blood pressure > 145/100 mm Hg - Allergic to eggs or spinach |
Αποτέλεσμα
Πρωτεύοντα αποτελέσματα
1. Plasma lutein [1 year]
2. Plasma choline [1 year]
3. Plasma Zeaxanthin [1 year]
Δευτερεύοντα αποτελέσματα
1. Plasma lipids [1 year]
2. Plasma glucose [1 Year]
