Impact of Acetazolamide in Reducing Referred Postoperative Pain
Λέξεις-κλειδιά
Αφηρημένη
Ημερομηνίες
| Τελευταία επαλήθευση: | 06/30/2020 |
| Πρώτα υποβλήθηκε: | 08/26/2018 |
| Υποβλήθηκε εκτιμώμενη εγγραφή: | 07/12/2020 |
| Δημοσιεύτηκε για πρώτη φορά: | 07/13/2020 |
| Υποβλήθηκε τελευταία ενημέρωση: | 07/12/2020 |
| Δημοσιεύτηκε η τελευταία ενημέρωση: | 07/13/2020 |
| Ημερομηνία έναρξης της πραγματικής μελέτης: | 08/21/2018 |
| Εκτιμώμενη κύρια ημερομηνία ολοκλήρωσης: | 11/30/2020 |
| Εκτιμώμενη ημερομηνία ολοκλήρωσης μελέτης: | 07/31/2021 |
Κατάσταση ή ασθένεια
Παρέμβαση / θεραπεία
Drug: Acetazolamide
Other: Placebo
Φάση
Ομάδες βραχιόνων
| Μπράτσο | Παρέμβαση / θεραπεία |
|---|---|
| Active Comparator: Acetazolamide Group 1 (acetazolamide): Patients undergoing RALP with the peri-operative use of one-time 250 mg dose of acetazolamide | Drug: Acetazolamide Being that adequate pain control is essential to recovery in the post-operative setting, efforts have been made to address this pain at its root. Prior studies have demonstrated that preoperative administration of acetazolamide decreased post-operative referred pain in the immediate post-surgical period. |
| Placebo Comparator: Placebo Group 2 (placebo): Patients undergoing RALP with the peri-operative use of 10 mL normal saline as placebo. | Other: Placebo Group 2 (placebo): Patients undergoing RALP with the peri-operative use of 10 mL normal saline as placebo. |
Κριτήρια καταλληλότητας
| Επιλέξιμες ηλικίες για μελέτη | 18 Years Προς την 18 Years |
| Φύλα επιλέξιμα για μελέτη | Male |
| Δέχεται υγιείς εθελοντές | Ναί |
| Κριτήρια | Inclusion Criteria: • Male patients ≥18 years of age undergoing robotic-assisted prostatectomy Exclusion Criteria: - Patients with renal insufficiency with serum creatinine >2.0 mg/dl - Patients with renal transplant - Patients with pre-existing metabolic acidosis - Patients with chronic obstructive pulmonary disease - Patients with hepatic disease - Patients with central nervous system disorders - Patients with hematological disease history - Patients with pre-existing electrolyte abnormalities - Patients with hypovolemia - Patients with lithium or diuretic usage - Patients with sulfonamides allergy - Patients with American Society of Anesthesiologists physical status 4 or 5 |
Αποτέλεσμα
Πρωτεύοντα αποτελέσματα
1. Visual Analogue Scale (VAS) 10-cm lines anchored at the ends by words that define the bounds of various pain dimensions. The patient is asked to place a vertical mark on the scale to indicate the level of intensity of his pain. [24 hours]
