Scrub Typhus Infection Induced Cardiovascular Disease
Λέξεις-κλειδιά
Αφηρημένη
Περιγραφή
Scrub typhus is a zoonotic disease caused by Orientia tsutsugamushi confined to East Asia including South Korea. It is characterized by fever, headache, rash, and eschar and the majority of patients without complications can recover with an early diagnosis and proper management with antibiotics. However, the increasing mortality rate of scrub typhus has been recently reported in Southeast Asia. Severe complications can be manifested by respiratory distress syndrome, renal failure, hepatic failure, and cardiovascular disease. Especially, cardiovascular complications can lead to cardiogenic shock and sudden cardiac arrest. Therefore, the association and predictors for scrub typhus induced cardiovascular disease should be investigated to provide a timely and appropriate diagnosis and to reduce the mortality rate of complicated scrub typhus infection. Therefore, investigators prospectively investigate the association and predictors of cardiovascular disease in the participants with scrub typhus infection admitted to 3rd referral centers in South Korea.
Ημερομηνίες
| Τελευταία επαλήθευση: | 09/30/2019 |
| Πρώτα υποβλήθηκε: | 09/02/2017 |
| Υποβλήθηκε εκτιμώμενη εγγραφή: | 09/05/2017 |
| Δημοσιεύτηκε για πρώτη φορά: | 09/06/2017 |
| Υποβλήθηκε τελευταία ενημέρωση: | 10/06/2019 |
| Δημοσιεύτηκε η τελευταία ενημέρωση: | 10/08/2019 |
| Ημερομηνία έναρξης της πραγματικής μελέτης: | 08/31/2017 |
| Εκτιμώμενη κύρια ημερομηνία ολοκλήρωσης: | 08/29/2020 |
| Εκτιμώμενη ημερομηνία ολοκλήρωσης μελέτης: | 08/29/2021 |
Κατάσταση ή ασθένεια
Παρέμβαση / θεραπεία
Other: No intervention
Φάση
Ομάδες βραχιόνων
| Μπράτσο | Παρέμβαση / θεραπεία |
|---|---|
| Scrub typhus without cardiovascular complications Any participants with the scrub typhus infection without cardiovascular complication will be enrolled as a positive control group during admission and clinically followed by 1 year after discharge | |
| Scrub typhus with cardiovascular complication Any participants with the scrub typhus infection with cardiovascular complication will be enrolled as a comparison group during admission and clinically followed by 1 year after discharge |
Κριτήρια καταλληλότητας
| Επιλέξιμες ηλικίες για μελέτη | 19 Years Προς την 19 Years |
| Φύλα επιλέξιμα για μελέτη | All |
| Μέθοδος δειγματοληψίας | Probability Sample |
| Δέχεται υγιείς εθελοντές | Οχι |
| Κριτήρια | Inclusion Criteria: - any participants with scrub typhus infection Exclusion Criteria: - patients under age of 18 - pregnancy |
Αποτέλεσμα
Πρωτεύοντα αποτελέσματα
1. Cardiovascular Mortality [one year]
Δευτερεύοντα αποτελέσματα
1. Cardiovascular Complications [one year]
