[Effect of aminophylline on fatigue of inspiratory muscles].

Effect of aminophylline on the fatigue of inspiratory muscles and ventilation disorders induced by respiratory resistive load was studied in cats. The administration of aminophylline on the background of inspiratory fatigue increases transdiaphragm pressure, restores bioelectric activity of inspiratory muscles and phrenic nerve, and decreases the respiratory duty cycle and rate. It is concluded that aminophylline in a dose of 24 mg/kg (i.v.) is capable of compensating the inspiratory muscle fatigue via both central and peripheral mechanisms, the latter effect being probably of greater importance.