5 Αποτελέσματα
BACKGROUND OF THE INVENTION
The present invention concerns a method for the detection of 5-methylcytosine in DNA. 5-Methylcytosine is the most frequent covalently modified base in the DNA of eukaryotic cells. It plays an important biological role, among other things, in the regulation of
BACKGROUND OF THE INVENTION
The present invention concerns a method for the detection of 5-methylcytosine in DNA. 5-Methylcytosine is the most frequent covalently modified base in the DNA of eukaryotic cells. It plays an important biological role, among other things, in the regulation of
BACKGROUND OF THE INVENTION
In eukaryotic organisms, DNA methylation is catalyzed by an S-adenosyl-L-methionine (AdoMet).sup.1-dependent DNA cytosine-C.sup.5 methyltransferase (DCMTase, EC 2.1.1.37). Methyl group transfer to the cytosine-C.sup.5 position occurs predominately within the
BACKGROUND OF THE INVENTION
In eukaryotic organisms, DNA methylation is catalyzed by an S-adenosyl-L-methionine (AdoMet).sup.1-dependent DNA cytosine-C.sup.5 methyltransferase (DCMTase, EC 2.1.1.37). Methyl group transfer to the cytosine-C.sup.5 position occurs predominately within the
BACKGROUND OF THE INVENTION
The present invention concerns a method for the quantification of methylated cytosine positions in DNA. 5-methylcytosine is the most commonly modified base in the DNA of eukaryotic cells. It plays an important biological roll in transcriptional regulation, genetic