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15 Αποτελέσματα
Thiamine deficiency in vitro accelerates A-type potassium current inactivation in cerebellar granule neurons.
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Σύνδεση εγγραφή
Thiamine deficiency during embryonic or early postnatal development causes deficits in cerebellum-dependent activities including motor control and procedural memory. Here, we give a detailed description of the changes to A-type current in cultured cerebellar granule neurons exposed to thiamine
Acute thiamine deficiency and refeeding syndrome: Similar findings but different pathogenesis.
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Σύνδεση εγγραφή
OBJECTIVE
Refeeding syndrome can occur in several contexts of relative malnutrition in which an overaggressive nutritional support is started. The consequences are life threatening with multiorgan impairment, and severe electrolyte imbalances. During refeeding, glucose-involved insulin secretion
Electrical properties of isolated cardiomyocytes in a rat model of thiamine deficiency.
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Σύνδεση εγγραφή
In modern society, thiamine deficiency (TD) remains an important medical condition linked to altered cardiac function. There have been contradictory reports about the impact of TD on heart physiology, especially in the context of cardiac excitability. In order to address this particular question, we
The contribution of mild thiamine deficiency and ethanol consumption to central cholinergic parameter dysfunction and rats' open-field performance impairment.
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Σύνδεση εγγραφή
We studied at the biochemical, morphological, and behavioral levels the effect of chronic ethanol consumption, associated or not with a mild thiamine deficiency episode. We found that (i) thiamine deficiency induced a significant decrease of the acetylcholinesterase (AChE) activity both in cortex
Thiamine deficiency during pregnancy leads to cerebellar neuronal death in rat offspring: role of voltage-dependent K+ channels.
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Σύνδεση εγγραφή
Oxidative stress, selective neuronal loss, and diminished activity of thiamine-dependent enzymes play a role in many neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease and Huntington's disease. To further understand the major implications of thiamine deficiency (TD) in
Development and validation of a dried blood spot test for thiamine deficiency among infants by HPLC-fluorimetry.
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Σύνδεση εγγραφή
Thiamine deficiency, if detected early in infancy, can be treated with thiamine supplementation and can prevent seizures, other disabilities and death. The dried blood spot (DBS) sampling technique is an attractive sample collection technique for infants. The present study reports the development
Effect of pyrithiamine treatment on potassium ion fluxes in rat cortical slices.
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Σύνδεση εγγραφή
The effect of thiamine deficiency on energy-requiring processes in brain tissue was studied by comparing cortical slices prepared from control and pyrithiamine-treated rats. Veratridine was used to stimulate energy metabolism by opening voltage-sensitive sodium channels resulting in enhanced Na+/K+
Determination of thiamine and its phosphate esters by gradient-elution high-performance liquid chromatography.
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Σύνδεση εγγραφή
A high-performance liquid chromatographic method for the determination of thiamine and its phosphate esters using gradient elution is presented. Chromatography was performed on an octadecyl C18 column with post-column derivatization using potassium ferricyanide: thiamine was oxidized to thiochrome,
Heart muscle disease among adult Nigerians: role of nutritional factors in its aetiology.
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Σύνδεση εγγραφή
A study of 44 Nigerians with heart muscle disease defined as congestive cardiac failure and cardiac enlargement of unknown cause with a presenting diastolic blood pressure of not more than 100 mm Hg has shown 20 were alcoholics. 12 of these belonged to the high socioeconomic class. 17 were thiamine
Excitatory effect of thiamin on CA1 pyramidal neurones in rat hippocampal slices in vitro.
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Σύνδεση εγγραφή
Clinically, acute thiamin deficiency may lead to Wernicke encephalopathy and fulminant cardial beriberi. Both diseases respond to high parenteral doses of thiamin. The cofactor role of intracellular thiamin diphosphate has been thoroughly investigated, but an additional acute effect of
Fifty-five-year personal experience with human nutrition worldwide.
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Σύνδεση εγγραφή
By 1950 the vitamins had been identified, but little was known of their functions. Beriberi, pellagra, and ariboflavinosis were disappearing, but kwashiorkor and/or marasmus were common in most developing countries. Requirements for protein were still uncertain, and those for essential amino acids
Neurological complications in hyperemesis gravidarum.
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Σύνδεση εγγραφή
Hyperemesis gravidarum can impair correct absorption of an adequate amount of thiamine and can cause electrolyte imbalance. This study investigated the neurological complications in a pregnant woman with hyperemesis gravidarum. A 29-year-old pregnant woman was admitted for hyperemesis gravidarum.
Micronutrient deficiencies after gastric bypass for morbid obesity.
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Gastric stapling for morbid obesity has been popularized, in part, because of an apparent lack of metabolic sequelae. Of our series of prospectively studied gastric bypass patients, 74 patients have been followed for more than 1 year. Anemia developed in more than one-third of the patients. Nearly
Mechanisms of ethanol-induced death of cerebellar granule cells.
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Σύνδεση εγγραφή
Maternal ethanol exposure during pregnancy may cause fetal alcohol spectrum disorders (FASD). FASD is the leading cause of mental retardation. The most deleterious effect of fetal alcohol exposure is inducing neuroapoptosis in the developing brain. Ethanol-induced loss of neurons in the central
Rapid HPLC measurement of thiamine and its phosphate esters in whole blood.
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BACKGROUND
Thiamine (vitamin B(1)) deficiency is associated with severe diseases such as beriberi and Wernicke encephalopathy. Although most Americans have sufficient dietary intake, thiamine deficiency is observed in the alcohol-dependent and elderly populations. Measurement of thiamine
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