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galanin/παχυσαρκία

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Σελίδα 1 από 163 Αποτελέσματα

Influence of obesity and menopausal status on serum leptin, cholecystokinin, galanin and neuropeptide Y levels.

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Σύνδεση εγγραφή
Obesity occurs in 60% of women after menopause and is characterized by an excess of adipose tissue that depends on several orexigenic (neuropeptide Y (NPY) stimulates carbohydrate ingestion, galanin stimulates fat intake) and anorectic (leptin, cholecystokinin (CCK)) factors. Both leptin and insulin

Low levels of plasma galanin in obese subjects with hypertension.

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Σύνδεση εγγραφή
BACKGROUND Obesity is strongly linked to increased blood pressure, which increases the risk of cardiovascular diseases. To our knowledge, little literature reported the information about galanin levels in obese individuals with hypertension. Therefore, the aim of this study was to investigate the

Galanin/GALP and galanin receptors: role in central control of feeding, body weight/obesity and reproduction?

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Σύνδεση εγγραφή
Scientific and commercial pharmacological interest in the role of galanin and galanin receptors in the regulation of food intake, energy balance, and obesity has waned recently, following initial enthusiasm during the 1980-1990s. It has been replaced by efforts to understand the role of newly

Galanin-like peptide mRNA alterations in arcuate nucleus and neural lobe of streptozotocin-diabetic and obese zucker rats. Further evidence for leptin-dependent and independent regulation.

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Σύνδεση εγγραφή
Galanin-like peptide (GALP) is a 60-amino-acid peptide with structural similarities to galanin and a high affinity for galanin receptors. GALP is expressed by a discrete population of neurons in the arcuate nucleus (ARC) and median eminence of the hypothalamus of several species, including the rat.

Obesity and endocrine dysfunction in mice with deletions of both neuropeptide Y and galanin.

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Σύνδεση εγγραφή
Neuropeptide Y (NPY) and galanin have both been implicated in the regulation of body weight, yet mice bearing deletions of either of these molecules have unremarkable metabolic phenotypes. To investigate whether galanin and NPY might compensate for one another, we produced mutants lacking both

Hypothalamic neuropeptide Y and galanin in overweight rats fed a cafeteria diet.

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Σύνδεση εγγραφή
We evaluated neuropeptide Y (NPY) and galanin (GAL) immunoreactivity (IR) and mRNA in the paraventricular and arcuate nucleus, respectively, in rats that became overweight (Ov) or not (NOv) when fed a cafeteria diet. After 2 months of diet, NOv rats showed a significant increase in NPY IR, whereas

The anorectic response to growth hormone in obese rats is associated with an increased rate of lipid oxidation and decreased hypothalamic galanin.

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Σύνδεση εγγραφή
The aim of this study was to demonstrate differential effects of growth hormone (GH) on food intake in lean and obese rats and to investigate whether an anticipated anorectic response in obese rats might be associated with increased lipid oxidation and altered hypothalamic neuropeptide levels. GH (4

Exaggerated feeding response to central galanin-like peptide administration in diet-induced obese rats.

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Σύνδεση εγγραφή
Galanin-like peptide (GALP) is a newly identified neuropeptide implicated in the regulation of metabolism and reproduction. GALP gene expression is decreased in the hypothalamus of genetically obese rodents, such as fa/fa rats and ob/ob mice, and central administration of GALP increases feeding in

Galanin-like peptide gene expression in the hypothalamus and posterior pituitary of the obese fa/fa rat.

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Σύνδεση εγγραφή
We examined the galanin-like peptide (GALP) gene expression in the arcuate nucleus (ARC) and posterior pituitary (PP) in 6- and 18-week-old male obese fa/fa rats. GALP mRNA in the ARC in fa/fa rats was significantly decreased in 6- and 18-week-old and GALP mRNA in the PP in fa/fa rats was

Hypothalamic galanin and early state of hyperphagia in obese Zucker rats.

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Σύνδεση εγγραφή
Galanin (GAL) stimulates food intake in normal rats when it is injected in different hypothalamic areas involved in feeding such as the paraventricular and ventromedial nuclei and the lateral hypothalamus. At adulthood, the hyperphagic obese Zucker rat is characterized by a general dysregulation of

The effect of galanin on baseline and GHRH-induced growth hormone secretion in obese children.

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Σύνδεση εγγραφή
We have evaluated the effect of the administration of galanin (Gal), a newly identified hypothalamic peptide, on baseline and GHRH-induced GH rise in five obese children and in seven controls. The GH response to GHRH (hpGRF(1-29), 1 microgram/kg i.v.), and to Gal (15 micrograms/kg/h for 1 h),

Critical effects of aging and nutritional state on hypothalamic neuropeptide Y and galanin gene expression in lean and genetically obese Zucker rats.

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Σύνδεση εγγραφή
We have investigated, by Northern blot analysis, the hypothalamic gene expression [messenger RNA (mRNA)] of two appetite stimulating neuropeptides, neuropeptide Y (NPY) and galanin (GAL) in lean (+/+) and genetically obese (fa/fa) Zucker rats at 11, 24 and 40 weeks of age and their responsiveness to

Plasma galanin concentrations in obese, normal weight and anorectic women.

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Σύνδεση εγγραφή
OBJECTIVE Galanin is believed to play a role in the control of eating behavior. No information is available on its concentrations in the biological fluids in human obesity, and this study aimed to clarify this. METHODS We measured plasma galanin and serum insulin levels in 30 obese, 35 normal weight

[The role of galanin in the etiology of obesity in young girls].

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Σύνδεση εγγραφή
Serum galanin, FSH, LH and estradiol levels were measured in 36 young obese women and in 16 young women with normal weight and normally menstruating (control group). Obese young women were characterized by higher serum galanin levels than normally menstruating women. There were no differences in

Effects of fluoxetine administration on regional galanin expression in obese Zucker rat hypothalamus.

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Σύνδεση εγγραφή
The aim of the present work was to study the potential involvement of hypothalamic galanin system in the anorectic mechanism of fluoxetine in obese Zucker rats. Male obese Zucker (fa/fa) rats were administered fluoxetine (10 mg/kg; i.p.) daily for two weeks. The control group was given 0.9% NaCl
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