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14 Αποτελέσματα
The effect of conversion from cyclosporine to tacrolimus on gingival hyperplasia, hirsutism and cholesterol.
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Σύνδεση εγγραφή
The use of cyclosporine for immunosuppression in renal transplantation allograft recipients is associated with hypertrichosis, gingival hyperplasia, and hypercholesterolemia. Conversion of patients to tacrolimus may lead to an improvement in these effects with minimal risk of rejection or allograft
What is the calcineurin inhibitor of choice for pediatric renal transplantation?
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Σύνδεση εγγραφή
Cyclosporine microemulsion (CyA) and tacrolimus (Tac) are the principal immunosuppressants prescribed for adult and pediatric renal transplantation. In the majority of patients, these calcineurin inhibitors have been used in combination with other immunosuppressive drugs, such as azathioprine or
Primary and membranous dysmenorrhea.
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Σύνδεση εγγραφή
Organic, physiologic, and psychologic causes of dysmenorrhea are presented. Signs and symptoms include pelvic fullness, nausea, vomiting, diarrhea, urinary frequency, nervousness, and headaches. Primary dysmenorrhea has been treated with analgesics, diuretics, and antispasmodics. Androgen therapy
[Extended cyclosporine-A--treatment for severe chronic urticaria].
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BACKGROUND
In patients suffering from severe chronic urticaria (CU) and in whom both antihistamine therapy and short courses of corticosteroids are needed, cyclosporine-A (CsA) should be considered. In such patients CsA given for 1-3 months (3mg/kg/d) was reported to induce in 2/3 of patients a full
The effects of metformin on body mass index and glucose tolerance in obese adolescents with fasting hyperinsulinemia and a family history of type 2 diabetes.
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OBJECTIVE
The prevalence of type 2 diabetes in American adolescents has increased markedly during the past generation. Although the factors that contribute to the development of type 2 diabetes are complex and not wholly elucidated, the triad of severe obesity, hyperinsulinemia, and a family history
[Adverse effects of cyclosporin a observed in rheumatoid arthritis and psoriatic arthritis].
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BACKGROUND
Rheumatoid arthritis (RA) and psoriatic arthritis (PA) represent diseases which often demand aggressive therapy in order to control the process and inhibit lesion formation in joints and organs. This kind of therapy can be achieved with cyclosporin A (CsA), particularly when combined with
Open-label, multicenter study on the safety, tolerability, and efficacy of Simulect in pediatric renal transplant recipients receiving triple therapy with cyclosporin, mycophenolate, and corticosteroids.
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BACKGROUND
Basiliximab is a monoclonal antibody directed to the interleukin-2 receptor. Several studies have demonstrated both its efficacy and safety. Even with the use of polyclonal antibodies in renal pediatric transplant recipients, the local incidence of steroid-resistant rejections has been
Multicenter randomized trial comparing tacrolimus (FK506) and cyclosporine in the prevention of renal allograft rejection: a report of the European Tacrolimus Multicenter Renal Study Group.
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BACKGROUND
To confirm the results of a number of studies conducted in Europe, the United States, and Japan, this multicenter, randomized trial compared the 12-month efficacy and safety of tacrolimus- and cyclosporine-based immunosuppressive regimens in the prevention of renal allograft
Experience of FK506 immune suppression in pediatric heart transplantation: a study of long-term adverse effects.
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BACKGROUND
Immunosuppression with FK506 for pediatric heart transplantation has been used in this institution since 1989. This study reports the unique toxicity of this macrolide agent in these heart transplant recipients.
METHODS
Between October 1989 and August 1994, 49 patients were managed with
Abrupt increase of tacrolimus blood levels during an episode of Shigella infection in a child after liver transplantation.
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Σύνδεση εγγραφή
The authors report the case of an 8-year-old girl who underwent a liver transplant at the age of 18 months because of biliary atresia. She was treated with cyclosporin for more than 5 years. Increased hirsutism prompted a change to tacrolimus therapy. During 11 months the mean tacrolimus level was
Mucopolysaccharidosis III in Mainland China: Natural History, Clinical and Molecular Characteristics of 34 Patients
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Σύνδεση εγγραφή
Objectives Sanfilippo syndrome (Mucopolysaccharidosis III, MPS III) is a rare autosomal recessive hereditary disease, which is caused by lysosomal enzyme deficiency. This study was operated to investigate clinical and molecular characteristics of patients with MPS III, which will improve the
[Treatments of steroid-dependent nephrotic syndrome in children].
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Σύνδεση εγγραφή
Primary nephrotic syndrome (NS) is the most common glomerular disease in children. It is characterized by massive proteinuria and hypoalbuminemia. It typically has a sudden onset and more than 70% of patients will experience at least one relapse. An immunological origin has long been postulated,
Osilodrostat, a potent oral 11β-hydroxylase inhibitor: 22-week, prospective, Phase II study in Cushing's disease.
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OBJECTIVE
In a 10-week proof-of-concept study (LINC 1), the potent oral 11β-hydroxylase inhibitor osilodrostat (LCI699) normalized urinary free cortisol (UFC) in 11/12 patients with Cushing's disease. The current 22-week study (LINC 2; NCT01331239) further evaluated osilodrostat in patients with
Cyperus rotundus L.: Traditional uses, phytochemistry, and pharmacological activities.
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UNASSIGNED
Cyperus rotundus L. (Cyperaceae) is a medicinal herb traditionally used to treat various clinical conditions at home such as diarrhea, diabetes, pyresis, inflammation, malaria, and stomach and bowel disorders. Currently, it is one of the most widespread, problematic, and economically
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- Οργανώστε τα ενδιαφέροντά σας και μείνετε ενημερωμένοι με την έρευνα ειδήσεων, τις κλινικές δοκιμές και τα διπλώματα ευρεσιτεχνίας
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* Όλες οι πληροφορίες βασίζονται σε δημοσιευμένη επιστημονική έρευνα
