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BACKGROUND
The etiology of hyperinsulinemic hypoglycemia in adolescents is similar to that of adults. Patients resistant to medical treatment may undergo pancreatectomy. Diazoxide is the mainstay of medical treatment. Rarely bone marrow suppression is reported due to diazoxide.
METHODS
An adolescent
Nonlethal endotoxemia was produced in conscious fasted rats by the intravenous (i.v.) administration of Salmonella enteritidis lipopolysaccharide (LPS) at a dose of 30 micrograms/100 g together with the typical acute-phase response of fever at 4 hr post-LPS. Also at 4 hr post-LPS both
Intravenous glucose tolerance test (ivGTT) and insulin releasing test (IRT) were performed in 32 cases with epidemic hemorrhagic fever (EHF). 23 patients had impaired glucose tolerance, 17 patients showed hyperinsulinemia in fasting state, 12 patients had flat insulin response curves and most
This laboratory previously reported that centrally administered interleukin 1 (IL-1) in fasted pentobarbital-anesthetized rats elicited significant hyperinsulinemic and febrile responses. In characterizing this putative central mechanism for the regulation of pancreatic insulin secretion,
Mosquitoes have distinct developmental and adult life history, and the vectorial capacity of females has been shown to be affected by the larval nutritional environment. However, little is known about the effect of developmental nutrition on insulin-signaling and nutrient storage. In this study, we
OBJECTIVE
To characterize late convalescence after hemorrhagic fever with renal syndrome (HFRS), i.e. metabolic disorders and their relation with arterial pressure (AP) and renal function.
METHODS
202 HFRS convalescents were followed up with measurements of AP, purin, carbohydrate and lipid
After an intravenous glucose load in man, total serum amino acid concentrations are rapidly depressed and remain below baseline values for at least 2 to 3 hr after serum glucose and insulin have returned to preload concentrations. Despite the presence of basal hypoaminoacidemia, a decreased glucose
OBJECTIVE
Insulin has opposing influences on blood pressure by simultaneously increasing adrenergic activity and vasodilatating peripheral blood vessels. In this study, we sought to determine whether hyperinsulinemia affects tilt table responses in older adults with type 2 diabetes not complicated
Type 2 diabetes is associated with biochemical evidence of low-grade inflammation, and experimental studies have suggested that both insulin and glucose affect inflammatory responses. To determine the effect of in vivo changes in glucose availability and plasma insulin concentrations in humans, we
OBJECTIVE
The aim of the study was to characterize seizures and epilepsy related to hypoglycaemia.
METHODS
We analyzed the files of 170 consecutive patients referred for hypoglycaemia (onset 1h to 4y) caused by inborn errors of metabolism (glycogen storage disease type I, fatty acid β-oxidation
In eukaryotic cells ATP is generated by oxidative phosphorylation, an energetic coupling at the mitochondrial level. The oxidative reactions occurring in the respiratory chain generate an electrochemical proton gradient on both sides of the inner membrane. This gradient is used by the ATPsynthase to
We determined the role of prostanoids in mediating alterations in glucose metabolism during lipopolysaccharide (LPS)-induced (1 mg/kg; LD10) acute endotoxemia in chronically catheterized awake rats. Basal glucose turnover (Rt, infusion of [5-3H]glucose), in vivo insulin action on overall glucose
Diseases as different as cardiac arrhythmias, epilepsy, myotonia, malignant hyperthermia, familial hyperinsulinism, and Bartter syndrome have all been linked to mutations in genes encoding ion channels. This has been made possible by an exciting and fruitful collaboration between clinicians,
Barrows were restrictively fed starting at 20 kg BW to determine the effects of endotoxin on growth performance of control and somatotropin-treated pigs. The following treatments were used: 1) daily i.m. vehicle injection until 55 kg BW; 2) daily i.m. injections of 100 micrograms of recombinant