The toxic hazard to the eye from dichloromethane (DCM) as liquid or vapour has been assessed rabbits. 0.1 ml DCM caused inflammation of the conjunctiva and eyelids persisting for up to 2 weeks; keratitis and iritis occurred in two-thirds of the animals. Corneal thickness, measured in vivo, increased
The crude extract and hexane, dichloromethane, and methanol fractions obtained from the aerial parts of Pterocaulon polystachyum (Asteraceae) were assayed against Acanthamoeba castellanii, a free-living ameba that causes acute amebic keratitis. Because of its capacity to form cysts, some strains of