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ligustrazine/hypoxia
Ο σύνδεσμος αποθηκεύεται στο πρόχειρο
Σελίδα 1 από 19 Αποτελέσματα
[Effect of ligustrazine on injury of vascular endothelial cells ECV-304 induced by hypoxia and lack of glucose].
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Σύνδεση εγγραφή
OBJECTIVE
To investigate the effects of ligustrazine on nitric oxide (NO), malonaldehyde (MDA) production, release of intracellular lactate dehydrogenase (LDH) and membrane fluidity of the injured human umbilical vein vascular endothelial cell line (ECV-304) with hypoxia and lack of
Effect of ligustrazine on pulmonary vascular changes induced by chronic hypoxia in rats.
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Σύνδεση εγγραφή
1. Acute and chronic effects on the pulmonary circulation of ligustrazine, a chemically identified and synthesized principle of a Chinese herb, were studied in rats. It dilated lung vessels and reversed hypoxic pulmonary vasoconstriction. 2. In rats kept 2 weeks in 10% O2 in a normobaric chamber and
[Effect of ligustrazine on cell cycle and prostacyclin of injured vascular endothelial cells induced by hypoxia and lack of glucose].
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Σύνδεση εγγραφή
OBJECTIVE
To study the effects of ligustrazine on cell cycle and prostacyclin of injured human umbilical vein vascular endothelial cell line induced by hypoxia and lack of glucose.
METHODS
The experiments were performed by culturing vascular endothelial cell induced by hypoxia and lack of glucose in
[Changes of the brain NSE, S100 and effect of ligustrazine in rats of chronic hypoxia and hypercapnia].
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Σύνδεση εγγραφή
OBJECTIVE
To investigate the changes of the brain NSE, S100 and ultrastructure and effect of ligustrazine in rats of chronic hypoxia and hypercapnia.
METHODS
Thirty rats were randomly divided into three groups: control group (A), hypoxia hypercapnia group (B), hypoxia hypercapnia added ligustrazine
Ligustrazine promoted hypoxia-treated cell growth by upregulation of miR-135b in human umbilical vein endothelial cells.
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Σύνδεση εγγραφή
[Effect of 764-3 and ligustrazine on collagen content of extrapulmonary arteries during chronic hypoxia].
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Σύνδεση εγγραφή
OBJECTIVE
Effect of two antifibrotic Chinese drugs, 764-3 and ligustrazine, on collagen content in chronic hypoxic pulmonary hypertensive extrapulmonary arterial wall were examined.
METHODS
Since collagen contains more than 10% hydroxyproline by weight and in other proteins there are almost no
Effect of Salvia miltiorrhiza and ligustrazine injection on myocardial ischemia/reperfusion and hypoxia/reoxygenation injury.
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Σύνδεση εγγραφή
Salvia miltiorrhiza and ligustrazine are traditional Chinese medicines that have been used in combination for treatment of cardiovascular disease, including coronary heart disease, cardiac angina and atherosclerosis in Asia, in particular, China. The present study aimed to determine the effect of S.
[Effect of Chinese medicine of nourishing kidney and clearing liver on intermittent hypoxia induced injury model of HUVECs through p38MAPK/NF-κB signaling pathway].
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Σύνδεση εγγραφή
This study aims to explore the intervention effect of Chinese medicine of nourishing kidney and clearing liver on intermittent hypoxia(IH) induced injury model of HUVECs through p38MAPK/NF-κB signaling pathway in vitro. HUVECs injury model was induced by modified IH treatment. The effective
[The effect of acute pulmonary alveolar hypoxia on canine plasma endothelin-1 levels].
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Σύνδεση εγγραφή
The effect of acute pulmonary alveolar hypoxia on plasma endothelin (ET)-1 levels was observed in 10 anesthetized dogs (hypoxic group). Plasma ET-1 like immunoreactivity (-LI) levels increased significantly at the fifth, fifteenth, sixtieth minute after hypoxia (fractional inspiratory O2
[Experimental study on acute hypoxia in newborn rabbits].
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Σύνδεση εγγραφή
To investigate the hypoxic-ischemic damage of perinatal asphyxia, the acute hypoxic models of newborn rabbits were established and the effects of ligustrazine and anisodamine on pulmonary arterial pressure (PAP), dural blood flow (DBF) and blood gas of the hypoxia rabbits were observed. Acute
[Changes of collagen distribution in extrapulmonary arteries of hypoxia-induced pulmonary hypertensive rat].
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Σύνδεση εγγραφή
Changes of collagen distribution in extrapulmonary arteries induced by hypoxia and the effects of ligustrazine (ligus) and 764-3 were investigated. Histological study showed that hypoxia could induce an increase of the medial and adventitial thickness of the pulmonary arterial trunk. An increase of
Nrf2 Activation Is Required for Ligustrazine to Inhibit Hepatic Steatosis in Alcohol-Preferring Mice and Hepatocytes.
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Σύνδεση εγγραφή
Hepatic steatosis is the most distinctive feature of alcoholic liver disease (ALD). Our previous in vivo study showed that ligustrazine, a major active alkaloid isolated from Ligusticum chuanxiong Hort, attenuated alcohol-induced hepatic steatosis and in vitro study revealed that nuclear factor
[Effect of shen mai injection and its combinations on blood gas and hemodynamics of rats exposed to chronic hypoxia].
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Σύνδεση εγγραφή
Shen Mai Injection (SMI) consisted of Panax ginseng and Ophiopogon japonica might promote the myocardial and diaphragmatic muscle contraction. The effect of SMI and its combinations were examined on the blood gas and hemodynamics of rats exposed to chronic hypoxia. SMI reduced significantly the
[Intervention effects and mechanism of Chinese herbal medicine of supplementing Qi and activating blood circulation on chronic intermittent hypoxia composite insulin resistance ApoE~(-/-) mice model].
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Σύνδεση εγγραφή
This study aims to observe the intervention effects of Chinese herbal medicine of supplementing Qi and activating blood circulation on chronic intermittent hypoxia(CIH) composite insulin resistance(IR) mediated atherosclerosis(AS) mice model,and to observe the mechanism of SREBP-1 c signaling
Pulmonary vasodilator action of ligustrazine, active principle of a traditional Chinese remedy, in rats and ferrets.
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Σύνδεση εγγραφή
The action of ligustrazine on the pulmonary circulation was tested in isolated perfused rat lung in vitro and autoperfused ferret lower left lobe preparation in vivo. Ligustrazine reduced hypoxic pulmonary vasoconstriction in a dose-dependent manner. It had a lesser dilator effect on KCl-induced
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